Recruiting

Blood Flow Restriction

Sponsor:

University of Illinois at Chicago

Code:

NCT07003113

Conditions

Low Back Pain

Knee Osteoarthritis

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Interventions

Ischemic Preconditioning

Sham Intervention

Study Details

Brief summary:

We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.

Conditions

Low Back Pain

Knee Osteoarthritis

Study ID

NCT07003113

Start date

Sep 12, 2025

Status verified date

Jun, 2025

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Jul 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Reported Knee Pain using ACR Criteria
  • Reported Back Pain using ODI Criteria > 12
  • Ability to walk for at least 3 minutes without the use of aids
  • Ability to provide written informed consent

Exclusion Criteria:

  • Younger than 50 years old
  • History of Knee or Hip Replacements
  • History of steroid injection within the previous 6 months
  • Presence of neuromuscular joint condition that affects lower extremity function
  • History of blood clots in the leg or any condition in which compression of the thigh is contraindicated
  • History of heart failure or thrombosis
  • Allergic to ultrasound gel
  • History of spine surgery
  • Non-English speaker
  • Currently pregnant or intends to become pregnant during the study

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: IC Arm

sham comparator: Sham Arm

Interventions

Ischemic Preconditioning

The intervention arm will include full blood flow occlusion in one thigh for 5 minutes followed by 5 minutes of reperfusion for a cycle of 50 minutes.

Sham Intervention

This intervention includes 25mmHg of pressure, which is not sufficient for blodo flow occlusion.

Primary outcome measure

  • Preferred walking speed [ Time Frame: At baseline (from enrollment) until end of intervention (3 weeks). ]
  • Muscle strength [ Time Frame: From baseline (enrollment) until end of intervention (3 weeks) ]
  • Patient Reported Outcomes [ Time Frame: At baseline (enrollment) through the intervention (3 weeks) ]
  • Gait Kinematics [ Time Frame: At baseline (from enrollment) until end of intervention (3 weeks). ]
  • Gait Kinetics/Moments [ Time Frame: At baseline (from enrollment) until end of intervention (3 weeks). ]

Central Contacts and Locations

Central contacts

Shraddha Sudhir

312-413-5118ssudhi5@uic.edu

Locations

Human and Sport Performance Lab

Recruiting

Chicago, Illinois, United States, 60608

Contacts

Shraddha Sudhir

312-413-5118ssudhi5@uic.edu

More Information

Sponsor

University of Illinois at Chicago

Last update posted

Nov 17, 2025

Last verified

Jun, 2025

Keywords

  • ischemic preconditioning
  • restricted blood flow
  • knee pain
  • back pain

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of Illinois at Chicago on 2025-11-17.