Recruiting

PSV vs. ATC

Sponsor:

Rush University Medical Center

Code:

NCT07005505

Conditions

Spontaneous Breathing Trial in ICU

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Pressure Support Ventilation (PSV)

Automatic tube compensation (ATC)

Study Details

Brief summary:

For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.

Conditions

Spontaneous Breathing Trial in ICU

Study ID

NCT07005505

Start date

Jun 1, 2025

Status verified date

Jun, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Jul, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Admitted to intensive care unit (ICU)
  • Age 18 years or older
  • Requiring invasive mechanical ventilation for at least 24 hours
  • Pass spontaneous breathing trial screen criteria

Exclusion Criteria:

  • Clinical decision made not to proceed with extubation regardless of spontaneous breathing trial (SBT) results
  • Do not intubate (DNI) order
  • Presence of tracheostomy
  • Pregnancy
  • Known prisoner
  • Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures
  • Enrolled in another clinical trial that impacts ventilator weaning or liberation

Study Design

Enrollment

880 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Adult Intensive Care Unit (AICU)

experimental: Medical Intensive Care Unit (MICU)

experimental: Cardiosciences Intensive Care Unit (CSICU)

experimental: Neuroscience Intensive Care Unit (NSICU)

Interventions

Pressure Support Ventilation (PSV)

Spontaneous breathing trials will be conducted using the mode pressure support ventilation (PSV) with settings of a pressure support of 5 cmH2O and positive end expiratory pressure (PEEP) 5 cmH2O.

Automatic tube compensation (ATC)

Spontaneous breathing trials will be conducted using the mode automatic tube compensation (ATC) with settings of 100% tube compensation and a positive end expiratory pressure (PEEP) of 5 cmH2O.

Primary outcome measure

  • Reintubation [ Time Frame: Within 48 hours of extubation ]
  • Death [ Time Frame: Within 48 hours of extubation ]

Central Contacts and Locations

Central contacts

Jie Li, PhD

312-563-4643Jie_Li@rush.edu

Lauren Harnois, MSc

Lauren_J_Harnois@rush.edu

Locations

Rush University Medical Center

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Jie Li, PhD

3125634643jie_li@rush.edu

Lauren Harnois, MS

Lauren_J_Harnois@rush.edu

More Information

Sponsor

Rush University Medical Center

Last update posted

Jul 2, 2026

Last verified

Jun, 2026

Keywords

  • Ventilator liberation
  • Spontaneous breathing trial

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Rush University Medical Center on 2026-07-02.