Recruiting

Modified Fasting

Sponsor:

Mayo Clinic

Code:

NCT07006142

Conditions

Upper Endoscopy

GLP1-R-related Disease

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Modified Fasting Guidelines

Study Details

Brief summary:

The aim of this study is to determine whether a modified fasting protocol can reduce the potential risk of aspiration for patients currently prescribed GLP1-RAs.

Conditions

Upper Endoscopy

GLP1-R-related Disease

Study ID

NCT07006142

Start date

Aug 1, 2025

Status verified date

Jun, 2026

Completion date

Aug 30, 2026

Anticipated

Primary completion date

Aug 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients undergoing elective upper endoscopy with gastroenterology team

Exclusion Criteria:

  • Urgent or emergent procedure
  • Inclusion of colonoscopy or antegrade small bowel enteroscopy in planned procedure
  • Upper GI barium study performed in past 24 hours.
  • Gastroparesis
  • Achalasia
  • Pancreatitis
  • Use of outpatient pro-motility medications
  • Patient refusal
  • Inability for patient to provide own consent

Study Design

Enrollment

150 participants

Anticipated

Intervention Model

Single group

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

no intervention: Normal fasting guidelines and not taking GLP1-RAs

Patients who are not taking GLP1 RAs (Receptor Agonists) and who will abide by the normal fasting guidelines

no intervention: Normal fasting guidelines with GLP1-RAs

Patients who are taking GLP1 RAs (Receptor Agonists) for either diabetes or weight loss management who will abide by normal fasting guidelines

experimental: Modified fasting guidelines with GLP1-RAs

Patients who are prescribed and taking GLP1 RAs (Receptor Agonists) for either diabetes or weight loss management who follow the modified fasting guidelines. Modified fasting consists of a full-liquid diet 48 hours prior to the procedures, clear liquid diet 24 hours prior to their procedure, and nothing by mouth (NPO) after midnight on the day of their procedure.

Interventions

Modified Fasting Guidelines

Patients will follow a full-liquid diet 48 hours prior to their procedure, clear liquid diet 24 hours prior to their procedure, and nothing by mouth (NPO) after midnight on the day of their procedure

Primary outcome measure

  • Gastric contents [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Krishnan Ramanujan, MD

507-422-4898ramanujan.krishnan@mayo.edu

Locations

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Krishnan Ramanujan, MD

507-422-4898ramanujan.krishnan@mayo.edu

More Information

Sponsor

Mayo Clinic

Last update posted

Jun 3, 2026

Last verified

Jun, 2026

Keywords

  • GLP1 receptor agonists
  • upper endoscopy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-06-03.