Recruiting

YES-CAN!

Sponsor:

University of Colorado, Denver

Code:

NCT07009509

Conditions

Nicotine Vaping

Eligibility Criteria

Sex: All

Age: 9+

Healthy Volunteers: Accepted

Interventions

YES-CAN! program

Study Details

Brief summary:

The goal of this pilot study is to determine the feasibility of a randomized trial of the YES-CAN! (Youth Engaged Strategies to Change Adolescent Norms) program to prevent nicotine vaping among adolescents. The program integrates the following evidence-based strategies: youth-adult collaboration; youth-developed narrative videos to convey health messages; peer leaders as change agents; and sustained implementation to change the normative environment. Two middle/high school communities will receive the YES-CAN! intervention. In each school community, a trained teacher will deliver a credit-earning middle or high school class to 25-30 middle or high school students, who will produce 6-8 short videos intended to increase refusal skills; promote stress management and positive coping; change social norms; prevent vaping initiation; and promote vaping cessation among current users. Videos will use a narrative approach and integrate known determinants of vaping. Middle or high school students will collaborate with the teacher and researchers to develop discussion guides and skills-building activities based on best practices for substance use prevention. In 6-8 sessions, middle or high school students will deliver their videos to all students in the associated middle school. A text messaging or other media component will reinforce and boost the effectiveness of the classroom sessions.

Aims for this pilot/feasibility study are:

1. To determine the feasibility and acceptability of implementing the YES-CAN! program
2. To determine the feasibility and acceptability of the research protocols that will be used in a future efficacy trial

Conditions

Nicotine Vaping

Study ID

NCT07009509

Start date

Aug 15, 2024

Status verified date

Jul, 2025

Completion date

Oct 30, 2026

Anticipated

Primary completion date

Oct 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 9+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Children enrolled in middle school grades 6-8 and high school grades 9-12 (age approximately 10-13 and 14-17); adults (over age 18) involved in educational system

Exclusion Criteria:

  • Not able to read and write in English or Spanish

Study Design

Enrollment

1166 participants

Anticipated

Intervention Model

Single group

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: YES-CAN! Intervention

A credit-earning middle or high school course that includes curriculum related to vaping, health risk communication, and video production will be established and approximately 25-30 students will be enrolled. Students will produce 6-8 short videos intended to increase refusal skills; promote stress management and positive coping; change social norms; prevent vaping initiation; and promote vaping cessation among middle school students. Videos will use a narrative approach and integrate known determinants of vaping. Students will collaborate with the teacher and researchers to develop discussion guides and skills-building activities based on best practices for substance use prevention. Students will deliver their videos, along with discussion and supportive activities, to all students in the associated middle school. A text message campaign will reinforce and boost the effectiveness of the classroom sessions.

Interventions

YES-CAN! program

Youth Engaged Strategies to Change Adolescent Norms

Primary outcome measure

  • Ever vaped at baseline [ Time Frame: Baseline ]
  • Ever vaped at 9 months [ Time Frame: 9 months ]
  • Every vaped at 12 months [ Time Frame: 12 months ]

Central Contacts and Locations

Central contacts

Locations

University of Colorado Anschutz Medical Campus

Recruiting

Aurora, Colorado, United States, 80045

Contacts

More Information

Sponsor

University of Colorado, Denver

Last update posted

Jul 15, 2025

Last verified

Jul, 2025

Keywords

  • Nicotine Vaping
  • Adolescents
  • School
  • Behavior change
  • Social norms
  • Electronic cigarettes

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Colorado, Denver on 2025-07-15.