Recruiting

Resilience Intervention

Sponsor:

Massachusetts General Hospital

Code:

NCT07013435

Conditions

Lymphoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Health Education Program

SMART3RP-Lymphoma

Study Details

Brief summary:

The goal of this trial is to learn if a resilience intervention can lead to improvements in lymphoma survivors' quality of life.

Conditions

Lymphoma

Study ID

NCT07013435

Start date

Oct 6, 2026

Status verified date

Oct, 2026

Completion date

Aug, 2030

Anticipated

Primary completion date

Sep, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • English or Spanish speaking adults (18+ at time of enrollment)
  • Within 1-5 years of completing active treatment for lymphoma (includes surgery, chemotherapy, immunotherapy, radiation therapy, or other); individuals may be on maintenance treatment.

Exclusion Criteria:

  • Active psychiatric, medical concern or cognitive comorbidity as determined by the site PI or treating clinician

Study Design

Enrollment

254 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

active comparator: Health Education Program

Participants will participate in 8 weekly sessions.

Components include:

  • education on the co-occurrence of mental and physical problems
  • goal setting for health behavior change
  • self-monitoring

HEP is an active control condition for mind body programs and is structurally equivalent to SMART3RP

experimental: SMART3RP-Lymphoma

Participants will participate in 8 weekly sessions.

The intervention components include:

  • Eliciting the relaxation response (RR),
  • CBT strategies to improve stress management
  • Positive psychology strategies to achieve growth enhancement

Interventions

Health Education Program

8 weekly sessions that include education on the co-occurrence of mental and physical problems, goal setting for health behavior change, and self-monitoring. Each session includes basic didactic information, interactive application of the information, and open discussion of didactic material.

SMART3RP-Lymphoma

The SMART3RP-lymphoma is a group program that, through a variety of mind-body approaches, such as imagery, relaxation, and yoga, seeks to buffer stress and promote psychological resiliency and physical well-being.

Primary outcome measure

  • Quality of Life (QoL): Change in PROMIS-29 [ Time Frame: From enrollment to 6 month follow up ]

Central Contacts and Locations

Locations

Sylvester Comprehensive Cancer Center

Recruiting

Miami, Florida, United States, 33136

Contacts

Frank Penedo, PhD

305-284-4290frank.penedo@miami.edu

Mass General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Giselle K Perez, PhD

617-724-0765gperez@mgh.harvard.edu

Principal Investigator:

Giselle K Perez, PhD

Huntsman Cancer Institute

Recruiting

Salt Lake City, Utah, United States, 84112

Contacts

Anne Kirchhoff, PhD

801-587-4084Anne.Kirchhoff@hci.utah.edu

Principal Investigator:

Anne Kirchhoff, PhD

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Oct 26, 2026

Last verified

Oct, 2026

Keywords

  • quality of life
  • psychosocial intervention
  • supportive care
  • cancer survivorship
  • resilience

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-13. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-10-26. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.