Recruiting

Mind Body Resilience

Sponsor:

Massachusetts General Hospital

Code:

NCT07014293

Conditions

Lymphoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Enhanced Usual Care

SMART3RP-Lymphoma

Study Details

Brief summary:

The goal of this clinical trial is to learn if a mind body resilience group program can help increase lymphoma survivors' ability to cope with and manage the challenges that come with the transition into early post treatment survivorship.

Conditions

Lymphoma

Study ID

NCT07014293

Start date

Aug 31, 2026

Status verified date

Aug, 2026

Completion date

Jul 1, 2030

Anticipated

Primary completion date

Jul 1, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • English speaking adult (18 years or older at enrollment)
  • At least 6-months post-lymphoma diagnosis and within 2 years of completing active, curative treatment for lymphoma (includes surgery, chemotherapy/immunotherapy/radiation therapy, or other)

Exclusion Criteria:

  • Active Psychiatric or cognitive comorbidity as determined by site PI or treating clinician
  • Unwilling or unable to participate using telehealth platform

Study Design

Enrollment

254 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

other: Enhanced Usual Care

Participants randomized to EUC will be referred to their site social work team. This most closely resembles the real-world care available to survivors on an outpatient basis. It is an enhanced version of usual care because proactive identification and referral of posttreatment survivors is not routinely done.

experimental: SMART3RP-Lymphoma

Participants will participate in 8 weekly group sessions, delivered virtually. The intervention components include: 1. Eliciting the relaxation response (RR) involves sustained mental focus with an attitude of open receptive awareness. 2. CBT to improve stress management involves increasing awareness and identification of the components of one's stress response (negative thoughts, emotions, physical reactions, behaviors, and relational) and learning skills at each session to alter these components (e.g., cognitive restructuring). 3. Positive psychology strategies to achieve growth enhancement focus on utilizing techniques and skills to promote positive growth. Skills focus on increasing social support, positive affect, and compassion.

Interventions

Enhanced Usual Care

Participants will receive a singleevaluation with a site social worker along with a list of mental health, social or community resources . This most closely resembles the real-world care available to survivors on an outpatient basis, however, we call this enhanced usual care since proactive identification and referral of posttreatment survivors is not routinely done.

SMART3RP-Lymphoma

The intervention components include: 1. Eliciting the relaxation response (RR) involves sustained mental focus with an attitude of open receptive awareness. 2. CBT to improve stress management involves increasing awareness and identification of the components of one's stress response (negative thoughts, emotions, physical reactions, behaviors, and relational) and learning skills at each session to alter these components (e.g., cognitive restructuring). 3. Positive psychology strategies to achieve growth enhancement focus on utilizing techniques and skills to promote positive growth. Skills focus on increasing social support, positive affect, and compassion.

Primary outcome measure

  • Change from Baseline in Coping Scores on the Measure of Current Status Scale (MOCS-A) [ Time Frame: Baseline to 3 month follow up ]

Central Contacts and Locations

Locations

Mass General Brigham

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Principal Investigator:

Giselle Perez, PhD

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Aug 11, 2026

Last verified

Aug, 2026

Keywords

  • coping
  • psychosocial intervention
  • survivorship
  • resilience

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-08-11.