Recruiting

Brain Response

Sponsor:

University of Michigan

Code:

NCT07014592

Conditions

Intractable Epilepsy

Eligibility Criteria

Sex: All

Age: 22 - 70+

Healthy Volunteers: Not accepted

Interventions

stimulating probes and electrodes

Study Details

Brief summary:

The goal of this project is to study how the brain reacts to a small electrical signal. Researchers will be using a novel combination of recording electrodes. The researchers will measure the brain response from these electrodes.

Conditions

Intractable Epilepsy

Study ID

NCT07014592

Start date

May 5, 2025

Status verified date

Jun, 2026

Completion date

Jun, 2028

Anticipated

Primary completion date

Jun, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 22 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients with medication intractable epilepsy who are recommended to undergo brain surgery to remove a "seizure" focus
  • Can provide informed consent for the study and willing to participate

Exclusion Criteria:

  • Presence of a permanent electronic implant
  • Any chronic medical conditions that prevent safe placement of electrodes

Study Design

Enrollment

5 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Medication-intractable epilepsy

Interventions

stimulating probes and electrodes

Subdural electrodes and/or ball tip probes will be used intraoperatively to provide electrical stimulation to the brain.

Primary outcome measure

  • Characterization of time-frequency data [ Time Frame: During a 20 minute research phase of a clinically indicated surgery ]
  • Characterization of local field responses (LFPs) [ Time Frame: During a 20 minute research phase of a clinically indicated surgery ]

Central Contacts and Locations

Central contacts

Ron Ball

734 936-7010rmball@umich.edu

Locations

University of Michigan

Recruiting

Ann Arbor, Michigan, United States, 48109

Contacts

Ron Ball

734-936-7010rmball@umich.edu

Principal Investigator:

Matthew Willsey, MD, PhD

More Information

Sponsor

University of Michigan

Last update posted

Jun 8, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Michigan on 2026-06-08.