Recruiting

Polypharmacy

Sponsor:

Icahn School of Medicine at Mount Sinai

Code:

NCT07022990

Conditions

Polypharmacy

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Interventions

Educational brochure for deprescribing

Study Details

Brief summary:

By 2030, the majority of World Trade Center (WTC) rescue and recovery workers (responders) will be aged 65 and over and at risk for aging-related conditions and consequences including the concurrent use of five or more medications (i.e., polypharmacy). The purpose of this research study is to investigate an educational approach targeting polypharmacy through de-prescribing unnecessary and burdensome medications via the support of informed discussions between WTC responders and their prescribing physicians.

Conditions

Polypharmacy

Study ID

NCT07022990

Start date

Apr 8, 2025

Status verified date

Jun, 2025

Completion date

Jun 30, 2026

Anticipated

Primary completion date

Jun 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • A WTC responder already enrolled in the "Promoting Healthy Aging Among WTC Responders: Frailty Trajectories and Intervention Strategies" study cohort
  • aged 50 years or older, and
  • taking one of the five medication classes:

  • proton pump inhibitors (PPIs),
  • benzodiazepine (BZs) and
  • non-benzodiazepine sedative hypnotics ("Z-drugs"),
  • first-generation antihistamines (FGA), and
  • skeletal muscle relaxants (SMR).

Exclusion Criteria:

  • None

Study Design

Enrollment

50 participants

Anticipated

Intervention Model

Single group

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: World Trade Center (WTC) Responders

World Trade Center (WTC) rescue and recovery workers (responders).

Interventions

Educational brochure for deprescribing

Study participant will be provided information (i.e., educational brochure) about one of the five medication classes participants may be taking that are known to have potential side effects for older adults: proton pump inhibitors (PPIs), benzodiazepine (BZs) and non-benzodiazepine sedative hypnotics ("Z-drugs"), first-generation antihistamines (FGA), and skeletal muscle relaxants (SMR) to determine their necessity.

Primary outcome measure

  • Brief Medication Questionnaire 2 (BMQ2) [ Time Frame: 6 months after study enrollment ]

Central Contacts and Locations

Central contacts

Patricia Kim

212-241-9370patricia.kim@mssm.edu

Locations

Icahn School of Medicine at Mount Sinai

Recruiting

New York, New York, United States, 10029

Contacts

Fred Ko, MD

212-241-9370fred.ko@mssm.edu

Patricia Kim, MBS

201-232-8578patricia.kim@mssm.edu

Principal Investigator:

Fred Ko

More Information

Sponsor

Icahn School of Medicine at Mount Sinai

Last update posted

Jun 15, 2025

Last verified

Jun, 2025

Keywords

  • Deprescribe
  • Medication management

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Icahn School of Medicine at Mount Sinai on 2025-06-15.