Recruiting

Resistance Training

Sponsor:

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Code:

NCT07023887

Conditions

Cancer

Breast Cancer

Eligibility Criteria

Sex: Female

Age: 20 - 70+

Healthy Volunteers: Not accepted

Interventions

6-12-25 Training Regimen

8x8 Training Regimen

5/5/5 Cluster Set Training Regimen

Double Training Regimen

Study Details

Brief summary:

This study investigates the impact of four standard of care, monitored group exercise regimens (resistance training) on conditioning and hypertrophy in women previously treated for breast cancer. The study will compare two conditioning regimens (6-12-25 and 8x8) and two hypertrophy regimens (5/5/5 cluster sets and double training) to assess changes in VO2 max, muscle mass, and fat mass.

Conditions

Cancer

Breast Cancer

Study ID

NCT07023887

Start date

May 21, 2025

Status verified date

Feb, 2026

Completion date

Oct 15, 2026

Anticipated

Primary completion date

Jul 15, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 20 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Age 20-89 years
2. Women prescribed exercise as a Standard of Care
3. Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
4. Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy.
5. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
6. Women with > 6 months of resistance training experience under expert guidance by a CSCS

Exclusion Criteria:

1. Any current treatment with cytotoxic chemotherapy for breast cancer
2. Inability to safely engage in group sessions of resistance training as deemed by study Pl
3. Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by Pl to be unsafe to engage in resistance training
4. Beta blocker or GLP-1 inhibitor medications
5. Pregnant women
6. Males

Study Design

Enrollment

15 participants

Anticipated

Interventions and Outcome Measures

Interventions

6-12-25 Training Regimen

A conditioning regimen involving three exercises performed consecutively with minimal rest. Includes 4-6 repetitions at 4-0-1-0 tempo, 10-12 repetitions at 3-0-1-0 tempo, and 20-25 repetitions at 2-0-1-0 tempo.

8x8 Training Regimen

A conditioning regimen optimizing high volume with short rest periods. Six exercises are performed consecutively with a 2-0-1-0 tempo and no rest between sets.

5/5/5 Cluster Set Training Regimen

A hypertrophy regimen where an individual performs 5 repetitions at a tempo of 4 seconds during the eccentric movement of the exercise, while performing the concentric motion in 1 second then resting for 20 seconds and repeating the sequence two additional times to total three clusters of 5 repetitions.

Double Training Regimen

A hypertrophy regimen adding an additional set of lesser repetitions for a specified exercise at the end of a tri-set of exercises.

Primary outcome measure

  • Change in VO2 max [ Time Frame: Measured monthly during the 5-month exercise program at weeks 4, 8, 12, 16, and 20. ]
  • Change in Muscle and Fat Mass [ Time Frame: Baseline, at the completion of the 5-month exercise program (Week 20), and monthly during the exercise program at weeks 4, 8, 12, and 16. ]
  • Change in Muscle and Fat Mass [ Time Frame: Baseline, at the completion of the 5-month exercise program (Week 20), and monthly during the exercise program at weeks 4, 8, 12, and 16. ]

Central Contacts and Locations

Central contacts

Clinical Trials Contact

412-330-6151ctgov@ahn.org

Locations

Allegheny General Hospital

Recruiting

Pittsburgh, Pennsylvania, United States, 15212

Contacts

Clinical Trials Contact

ctgov@ahn.org

More Information

Sponsor

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Last update posted

Feb 4, 2026

Last verified

Feb, 2026

Keywords

  • exercise

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) on 2026-02-04.