Recruiting

Alert with Triple-Testing

Sponsor:

University of Texas Southwestern Medical Center

Code:

NCT07031219

Conditions

HIV

HBV (Hepatitis B Virus)

HCV

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

electronic medical record alert linked to orders

Study Details

Brief summary:

Design:

This will be a within-subjects repeated-measures design, testing an electronic medical record pop-up alert linked to order panels for screening blood tests for human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). Study participants will be primary care providers. For each participating provider, their encounter will be randomized to either control (no alert; no changes to EMR interface) or an alert with triple-testing order panel intervention arm (alert linked to order panel with screening tests for all three bloodborne viruses (BBVs) selected by default; the alert will be triggered when a provider attempts to order a screening test for at least one BBV). The alert linked to triple testing orders will only be triggered if the provider orders a virus BBV screening test based on their normal practice and standard of care for their patient. Providers will see which orders are selected prior to signing (finalizing) them; therefore, this study will be unblinded. To mitigate the effect of unblinding, randomization will occur at the encounter level which will lead to providers experiencing both the control and intervention conditions randomly throughout the duration of the study.

Outcomes/endpoints:

The investigators will compare incidences of HIV, HBV, and HCV diagnoses between the two encounter conditions, estimate number of cases missed by not triple-testing, estimate laboratory costs per condition, and measure patient encounters per condition.

Conditions

HIV

HBV (Hepatitis B Virus)

HCV

Study ID

NCT07031219

Start date

Nov 1, 2026

Status verified date

Oct, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Outpatient primary care adult providers at participating institutions
  • Providers who provide consent to participate in this study.
  • Providers must intend to continue their current practice for at least 12 months.
  • Providers with at least 12 months experience in their current practice.

Exclusion Criteria:

  • Providers who do not consent to participate
  • Sub-specialty providers
  • Pediatric providers
  • Providers who anticipate leaving their current practice within the next 12 months (i.e. providers who plan to retire, move, etc.).
  • Providers with less than 12 months experience in their current practice (i.e. new providers or trainees who joined the practice within the last year)
  • Note: family medicine and med/peds providers can participate, but only for their adult patients. The intervention alert+order panel and any data collection will be restricted to adult patients ≥ 18 years old.

Study Design

Enrollment

50 participants

Anticipated

Intervention Model

Single group

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

other: Randomized encounters

For participating providers, each of their encounters will be randomized to either control (no alert; no changes to EMR interface; standard of care) or intervention (alert linked to triple testing orders will trigger when the provider attempts to order a screening test for HIV, hepatitis B, or hepatitis C). Since randomization will occur at the encounter level, participating providers will randomly experience control and intervention encounters throughout the duration of the study.

Interventions

electronic medical record alert linked to orders

An electronic medical record alert linked to triple testing orders will be built specifically for this study. An order for a screening blood test for any of the three bloodborne viruses (BBVs; i.e. HIV, hepatitis B virus (HBV), or hepatitis C virus (HCV)) will trigger an electronic medical record alert linked to orders for screening blood tests for all three BBVs to be selected by default. If participants accept the alert, the individual BBV order that triggered the alert will be replaced with the pre-selected screening orders for all three BBVs. If the participants dismiss the alert, the individual BBV screening test order that triggered the alert will be accepted without the addition of screening test orders for the other two BBVs. This alert with linked orders will only be available to participating providers throughout the duration of the study, and will only activate for encounters randomized to "intervention" encounters.

Primary outcome measure

  • Bloodborne virus (BBV) screening tests [ Time Frame: 24 months total: from 12 months pre-enrollment through the end of study participation (i.e. maximum of 1 year of participation) ]

Central Contacts and Locations

Central contacts

Nicole E Naiman, MD/PhD

214-645-9317nicole.naiman@utsouthwestern.edu

Stephanie Reyes

214-645-9317Stephanie.Reyes@UTSouthwestern.edu

Locations

University of Texas Southwestern Medical Center

Recruiting

Dallas, Texas, United States, 75390

Contacts

Nicole E Naiman, MD/PhD

2146459317nicole.naiman@utsouthwestern.edu

Stephanie Reyes

214-645-9317Stephanie.Reyes@UTSouthwestern.edu

Principal Investigator:

Mamta K Jain, MD, MPH

More Information

Sponsor

University of Texas Southwestern Medical Center

Last update posted

Oct 29, 2026

Last verified

Oct, 2026

Keywords

  • screening
  • provider orders
  • quality improvement

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-30. This information was provided to ClinicalTrials.gov by University of Texas Southwestern Medical Center on 2026-10-29. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.