Recruiting

Broccoli Microgreens

Sponsor:

University of Maryland, Baltimore

Code:

NCT07032545

Conditions

Obesity and Overweight

Breast Cancer Survivorship

Eligibility Criteria

Sex: Female

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Broccoli microgreen (BMG)

Study Details

Brief summary:

Obesity can pose significant challenges to maintaining long-term health in cancer survivors by increasing their risk of cancer coming back. Eating a healthy diet is an important way to help manage weight and improve overall health. Broccoli microgreens (BMG) are young broccoli plants packed with nutrients, and research suggests they may help prevent cancer.

Previous studies in mice showed that BMG can improve gut health and metabolism, leading to better health outcomes in obese animals. This study will test whether BMG can be a useful addition to the diet of obese breast cancer (BC) survivors who have a higher risk of their cancer returning.

24 obese BC survivors will be invited to eat one serving (one cup, \~57 gram) of fresh BMG every day for two weeks. This will help understand if people can stick to this diet, how their bodies respond, and whether it affects metabolism and inflammation-two key factors linked to cancer risk. Biological markers such as body fat, glucose and lipids as well as gut bacterial changes will be analyzed to see how BMG affects individual health.

This study may help create new diet strategies to improve health, reduce cancer risk, and support long-term recovery in cancer patients who are overweight or obese. In the future, this research could help doctors personalize nutrition plans to better support cancer survivors.

Conditions

Obesity and Overweight

Breast Cancer Survivorship

Study ID

NCT07032545

Start date

Dec 3, 2025

Status verified date

Dec, 2025

Completion date

Dec 31, 2028

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Female
  • Had a diagnosis of breast cancer (Stage I-III)
  • 2 to 60 months post-curative treatment (surgery, chemotherapy, and/or radiation)
  • BMI > 30 kg/m² (obese classification)
  • Willing to avoid cruciferous vegetables during the study
  • Able to sign an IRB-approved consent form

Exclusion Criteria:

  • Have any contraindications to the proposed nutrition intervention as identified by their medical provider, their designee, or the study team (e.g., GI conditions, medication requirements, pregnancy, breastfeeding, recent history of an eating disorder).
  • Allergy or intolerance to cruciferous vegetables
  • Currently taking broccoli extract supplements

Study Design

Enrollment

24 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: BMG

All participants are in BMG group and will consume one serving size (one cup, \~57 gram) of raw BMG daily for 2-week period of time.

Interventions

Broccoli microgreen (BMG)

All participants will consume one serving size (one cup, \~57 gram) of raw BMG daily for 2-week period of time.

Primary outcome measure

  • Feasibility, as Assessed by the Percentage of Participants Who Enrolled and Completed the Study [ Time Frame: 14 days ]
  • Compliance, as Assessed by the Percentage of the Participants Who Adhere to the Assigned BMG Intervention [ Time Frame: 14 days ]

Central Contacts and Locations

Central contacts

Yuanyuan (Rose) Li, M.D., Ph.D.

13014050776roseli15@umd.edu

Locations

Breast Evaluation and Treatment Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center

Recruiting

Baltimore, Maryland, United States, 21201

Contacts

Katherine Tkaczuk

410-328-7394ktkaczuk@umm.edu

More Information

Sponsor

University of Maryland, Baltimore

Last update posted

Dec 23, 2025

Last verified

Dec, 2025

Keywords

  • breast cancer
  • broccoli microgreen
  • obesity
  • survivorship
  • gut microbiome
  • metabolomics
  • metabotyping

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Maryland, Baltimore on 2025-12-23.