Recruiting

Mindfulness Training

Sponsor:

Washington University School of Medicine

Code:

NCT07040904

Conditions

Mindfulness

Alzheimer's Disease Related Dementia

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Accepted

Interventions

mindfulness

Study Details

Brief summary:

The primary objective of the proposed research is to investigate the promise and underlying mechanisms of mindfulness training as a preventative lifestyle intervention to enhance cognitive health in Latino older adults, thereby mitigating risk of Alzheimer's Disease (AD) in a population that may be particularly vulnerable.

Conditions

Mindfulness

Alzheimer's Disease Related Dementia

Study ID

NCT07040904

Start date

Dec 10, 2024

Status verified date

May, 2026

Completion date

Jul 31, 2026

Anticipated

Primary completion date

Jul 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Hispanic/Latino
  • Age 65 and older
  • Male, female, or non-binary
  • Community living
  • Medically stable and willing to undergo the study procedures
  • No extensive mindfulness training experience

Exclusion Criteria:

  • Clinically unstable psychiatric disorder that requires immediate treatment (e.g., ECT)
  • Medical conditions suggesting significantly shortened lifespan (e.g., metastatic cancer) or prohibiting safe participation in the interventions/assessments (e.g., Parkinson's disease, musculoskeletal conditions)
  • Sensory impairment (hearing, vision) preventing participation
  • Current alcohol or substance abuse
  • Current/concurrent cognitive training known to affect neuroplasticity (e.g., brain-training programs), or other interventions expected to affect neuroplasticity significantly (e.g., psychedelics, cholinesterase inhibitors, high-dose sedatives).

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Interventions

mindfulness

MBSR: Mindfulness Program A novel and culturally-adapted version of the well-validated mindfulness-based stress reduction (MBSR) course will be used for the intervention. The adapted program curriculum embeds core MBSR principles and practices within a culturally responsive didactic framework developed directly from community focus-group feedback. The course will be delivered via a group meeting across 8 weeks, with weekly classes held at a local community center. All classes will be held in hybrid format, with most participants attending in person, but with a live-stream option offered via Zoom.

Primary outcome measure

  • EEG brain markers of cognitive functioning [ Time Frame: Time-frame: 2 time-points - baseline/pre-intervention, and immediately after the intervention ]
  • EEG brain markers of cognitive functioning [ Time Frame: Time-frame: 2 time-points - baseline/pre-intervention, and immediately after the intervention ]
  • AXCPT behavioral performance (reaction time) [ Time Frame: Assessed at 2 timepoints: baseline/pre-intervention immediately post-intervention ]
  • AXCPT behavioral performance score (accuracy) [ Time Frame: Assessed at 2 timepoints: baseline/pre-intervention immediately post-intervention ]
  • Five Facet Mindfulness Questionnaire (FFMQ) score [ Time Frame: Performed during the intervention (3x /week for 8 weeks) ]
  • The Mindful Attention Awareness Scale (MAAS) score [ Time Frame: Performed during the intervention (3x /week for 8 weeks) ]
  • Cognitive and Affective Mindfulness Scale (CAMS-R) score [ Time Frame: Performed during the intervention (3x /week for 8 weeks) ]
  • Patient-Reported Outcomes Measurement Information System (Promis) score [ Time Frame: Performed during the intervention (3x /week for 8 weeks) ]
  • National Institutes of Health Toolbox Emotion Battery (NIH-TOOLBOX-EB) score [ Time Frame: baseline (pre-intervention) & immediately post-intervention ]

Central Contacts and Locations

Central contacts

Todd S Braver, Ph.D.

800-438-0445tbraver@wustl.edu

Diana Parra Perez, Ph.D.

parrad@wustl.edu

Locations

Washington University

Recruiting

St Louis, Missouri, United States, 63130

Contacts

Todd Braver

314-935-5143tbraver@wustl.edu

Diana Parra-Perez

parrad@wustl.edu

More Information

Sponsor

Washington University School of Medicine

Last update posted

May 11, 2026

Last verified

May, 2026

Keywords

  • AD Biomarkers
  • Alzheimer's Disease
  • Alzheimer's disease and related dementias
  • cognitive behavioral intervention
  • Mindfulness
  • Mindfulness Training

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Washington University School of Medicine on 2026-05-11.