Recruiting

MINT

Sponsor:

Northwestern University

Code:

NCT07041775

Conditions

Stroke

Stroke Gait Rehabilitation

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

myoelectric interface for neurorehabilitation (MINT) conditioning

One muscle myoelectric feedback

Study Details

Brief summary:

This study will test the ability of myoelectric interface for neurorehabilitation (MINT) training to improve walking function.

Conditions

Stroke

Stroke Gait Rehabilitation

Study ID

NCT07041775

Start date

Jun 4, 2026

Status verified date

Jun, 2026

Completion date

Mar, 2030

Anticipated

Primary completion date

Jan, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age at enrollment is 18 to 85
  • Leg impairment from unilateral stroke at least 6 months prior to screening
  • Severe to moderate gait impairment (ambulatory with a maximum walking speed of 0.8 m/s, i.e., half of normal speed)
  • Able to stand without assistance
  • Clinically observable gait asymmetry
  • Abnormal co-activation between adductor magnus and rectus femoris (R greater than or equal to 0.5)

Exclusion Criteria:

  • Cognitive impairment with at least moderately impaired attention on digit-span test, or unable to follow instructions of the MINT task
  • Visual impairment (such as hemianopia) preventing sufficient perception of the screen to play the games
  • Anesthesia or severe neglect in the affected leg, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest) that impairs ability to play the games
  • Participation in another study on the affected leg, or any pharmacological study, within 6 weeks of enrollment
  • Inability to understand or follow commands in English due to aphasia or other reason that makes it impossible to perform the training
  • Diffuse or multifocal infarcts
  • Substantial leg or other pain preventing participation for 60 minutes a day
  • Spasticity treatment (pharmacological or Botox) on the affected leg within past 3 months
  • Severe osteoporosis causing hip or other fractures
  • History of multiple falls within the last year, use of walker for balance, or falling during stance while in the lab in the first session.
  • Contracture limiting the range of motion of the leg
  • Current pregnancy
  • From the TMS portion of the study only: History of epilepsy in adulthood requiring antiseizure medications; recent/current alcoholism or benzodiazepine/barbiturate abuse or recent history of alcohol/benzodiazepine/barbiturate withdrawal, recent history of cocaine or amphetamine use, skull fractures or skull deficits, concussion within the last 6 months, unexplained recurring headaches, vagus nerve stimulator, cochlear implant, deep brain stimulator, intracranial/carotid stents, cardiac pacemaker/AICD.

Study Design

Enrollment

72 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: MINT group

MINT training of two leg muscles

sham comparator: Sham group

one muscle feedback

Interventions

myoelectric interface for neurorehabilitation (MINT) conditioning

Myoelectric interface for neurorehabilitation (MINT) conditioning involves training to reduce abnormal co-activation of limb muscles to improve movement.

One muscle myoelectric feedback

Training to control muscle activity in one muscle only.

Primary outcome measure

  • 10-m walk test [ Time Frame: Baseline and 4 weeks ]

Central Contacts and Locations

Central contacts

Marc Slutzky, MD, PhD

312-503-4653mslutzky@northwestern.edu

Cynthia Gorski

312-503-6097cynthia.gorski@northwestern.edu

Locations

Northwestern University

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Study Principal Investigator

312-503-4653mslutzky@northwestern.edu

More Information

Sponsor

Northwestern University

Last update posted

Jun 8, 2026

Last verified

Jun, 2026

Keywords

  • Stroke rehabilitation
  • Leg impairment
  • Walking
  • Rehabilitation gaming
  • Muscle biofeedback
  • Myoelectric interface

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Northwestern University on 2026-06-08.