Recruiting

Mango vs. Sucrose

Sponsor:

Ball State University

Code:

NCT07045051

Conditions

Healthy Participants

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Interventions

Low-Glycemic Breakfast Containing Oats and Mango

High-Glycemic Breakfast Containing Cereal and Mango

Low-Glycemic Breakfast Containing Oats and Table Sugar

High-Glycemic Breakfast Containing Cereal and Table Sugar

Study Details

Brief summary:

Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.

Conditions

Healthy Participants

Study ID

NCT07045051

Start date

Mar 26, 2025

Status verified date

Jun, 2025

Completion date

Dec 1, 2026

Anticipated

Primary completion date

Dec 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18 - 45 years.
  • Body mass index between 18.5-35.0 kg/m2
  • Not pregnant (females only)
  • Not postmenopausal (females only).
  • Not been diagnosed with cardiovascular disease.
  • Not been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
  • Not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • Does not regularly take anti-inflammatory drugs (more than 2x week).
  • Does not use glucose-lowering drugs (e.g., metformin)
  • Does not use lipid-lowering drugs (e.g., statins)
  • Does not use tobacco products or any illicit drugs.
  • Does not have a pacemaker.
  • Can consume mango, wheat, gluten, and milk.
  • Can stay in a supine position in the dark for at least ten minutes.

Exclusion Criteria:

  • Not between the ages of 18-45
  • Body mass index < 18.5 kg/m2 or >35.0 kg/m2
  • Pregnant (females only)
  • Postmenopausal status (females only).
  • Been diagnosed with cardiovascular disease.
  • Been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
  • Been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • Regularly take anti-inflammatory drugs (more than 2x week).
  • Uses glucose-lowering drugs (e.g., metformin)
  • Uses lipid-lowering drugs (e.g., statins)
  • Uses tobacco products or any illicit drugs.
  • Have a pacemaker.
  • Allergic to mango, wheat, gluten, and/or milk.
  • Unable to lay in supine position in the dark for at least ten minutes.

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Cereal Consumption with Mango

During the Cereal and Mango arm, participants will consume a bowl of corn flakes with 2% milk sweetened with fresh mango.

experimental: Cereal Consumption with Table Sugar

During the Cereal and Table Sugar arm, participants will consume a bowl of corn flakes with 2% milk sweetened with table sugar.

experimental: Oat Consumption with Mango

During the Oats and Mango Arm, participants will consume a bowl of oats prepared with water and sweetened with fresh mango.

experimental: Oat Consumption with Table Sugar

During the Oat and Table Sugar arm, participants will consume a bowl of oats prepared with water and sweetened with table sugar.

Interventions

Low-Glycemic Breakfast Containing Oats and Mango

Low-glycemic breakfast of 80 grams of oats prepared with 473mL water and sweetened with 146 grams of mango.

High-Glycemic Breakfast Containing Cereal and Mango

High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 262 grams of mango.

Low-Glycemic Breakfast Containing Oats and Table Sugar

Low-glycemic breakfast of 80 grams of oats prepared with 473mL of water and sweetened with 20 grams of table sugar.

High-Glycemic Breakfast Containing Cereal and Table Sugar

High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 36 grams of table sugar.

Primary outcome measure

  • Glucose [ Time Frame: Through study completion, up to 1.5 years. ]
  • Insulin [ Time Frame: Through study completion, up to 1.5 years. ]
  • Flow-mediated Dilation [ Time Frame: Through study completion, up to 1 year. ]

Central Contacts and Locations

Central contacts

Bryant Keirns, PhD

765-285-8356bryant.keirns@bsu.edu

Locations

Health Professions Building, Ball State University

Recruiting

Muncie, Indiana, United States, 47306

Contacts

Bryant Keirns, PhD

765-285-8356bryant.keirns@bsu.edu

More Information

Sponsor

Ball State University

Last update posted

Jul 1, 2025

Last verified

Jun, 2025

Keywords

  • glycemia
  • insulinemia
  • fresh mango
  • vascular health

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Ball State University on 2025-07-01.