Recruiting
Phase 1

Medtronic Percept RC

Sponsor:

The Cleveland Clinic

Code:

NCT07049003

Conditions

Tremor

Essential Tremor

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Not accepted

Interventions

Deep Brain Stimulation

Study Details

Brief summary:

This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System. The population will consist of patients that have either failed a prior intervention (Vim DBS or HIFU thalamotomy) or determined to not be suitable candidates for Vim DBS or HIFU thalamotomy because they have a cerebellar outflow or MS-related tremor. Those patients with a previous intervention, must have a prior diagnosis of ET, cerebellar outflow tremor, or MS-related tremor. Subjects without a previous intervention must have a diagnosis of cerebellar outflow tremor or MS-related tremor.

Conditions

Tremor

Essential Tremor

Study ID

NCT07049003

Start date

Jan 15, 2026

Status verified date

Jul, 2026

Completion date

Dec 31, 2029

Anticipated

Primary completion date

Dec 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 21 years and older;
  • Ability to give informed consent;
  • Diagnosis of ET, cerebellar tremor, or MS-related tremor with a failed a prior intervention (VIM DBS or HIFU thalamotomy) or determined to not be suitable candidates for VIM DBS or HIFU thalamotomy because they have a cerebellar outflow or MS-related tremor.
  • Tremor history of at least three years;
  • Tremor that is refractory to medical management;
  • A score of ≥24 on the Mini Mental State Examination;
  • Inability to successfully perform ADLs without assistance or has lost interest in social, professional, or personal activities due to tremor

Exclusion Criteria:

  • Any other neurological condition that could reduce the safety of study participation including central nervous system vasculitis and intracranial malignancy
  • A condition that, in the opinion of the clinical investigator, would significantly increase the risk or interfere with study compliance, safety, or outcome;
  • A diagnosis of dementia;
  • Tremors due to other neurological conditions such as Parkinson's disease, dystonia, or other conditions not consistent with ET, cerebellar outflow tremor, or MS-related tremor.
  • Diagnosis of epilepsy;
  • Major active and untreated psychiatric illness that may interfere with study, such as psychotic disorders or severe personality disorders;
  • Untreated or inadequately treated depression defined by a score of 20 or greater on the Beck Depression Inventory-II at the time of enrollment;
  • At risk for suicide defined by a score greater or equal to 3 on the Columbia Suicide Severity Rating Scale (C-SSRS);
  • Pregnancy;
  • Unable to communicate with investigators or staff;
  • Surgical contraindications to DN DBS;
  • Contraindication to magnetic resonance (MRI) imaging, e.g., weight incompatible with scanner, implanted metallic devices or electrical devices (pacemaker, defibrillator, spinal cord stimulator, prior DBS) or intolerance to MRI contrast agent;
  • Enrolled in another device, biologic or pharmaceutical study within 30 days of consent in the current study, (i.e., patient cannot be enrolled if participation in another study was not completed at least 30 days prior to consent.);
  • Evidence of behavior(s) consistent with alcohol or substance abuse/dependence as defined by the criteria outlined in the DSM-V within the preceding six months;
  • Injection of botulinum toxins into the arm, neck or face within six months prior to baseline;

Study Design

Enrollment

12 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Refractory Tremor

Medtronic Percept RC DBS System

Interventions

Deep Brain Stimulation

Deep Brain Stimulation of the Deep Cerebellar Nuclei

Primary outcome measure

  • The incidence and nature of treatment-related adverse events [ Time Frame: From DBS Implant Surgery through study completion, an average of 17 months ]

Central Contacts and Locations

Central contacts

Jeffrey Negrey, MA

2163166896negreyj2@ccf.org

Locations

Cleveland Clinic

Recruiting

Cleveland, Ohio, United States, 44195

Contacts

Jeffrey Negrey, MA

2163166896negreyj2@ccf.org

More Information

Sponsor

The Cleveland Clinic

Last update posted

Jul 10, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by The Cleveland Clinic on 2026-07-10.