Recruiting

Patient Navigation & PACT

Sponsor:

Fred Hutchinson Cancer Center

Code:

NCT07052630

Conditions

Hematopoietic and Lymphatic System Neoplasm

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Internet-Based Intervention

Patient Navigation

Best Practice

Survey Administration

Study Details

Brief summary:

This clinical trial evaluates the impact of patient navigation and the Planning Advance Care Together (PACT) website, either alone or in combination with one another, on advanced care planning (ACP) in patients with blood cancers who received a hematopoietic cell transplant (HCT). Engagement in ACP, including having goals of care conversations, improves quality of care at the end of life and supporting this should be included in all cancer survivorship care. Patient navigation is a healthcare service that is designed to guide a patient through the healthcare system and reduce barriers to timely screening follow-up, diagnosis, treatment, and supportive care. PACT is a web-based tool that provides information about ACP, assistance with documents for advanced directives, a supportive network and a forum for discussions about ACP. Patients who engage in ACP are more likely to have higher quality of life at the end of life, receive the care they want, die where they prefer, utilize hospice effectively, and are less likely to receive futile, aggressive care at the end of life. For HCT survivors at ongoing risk of death and other disease-related complications, having a plan in place for care they want is critical. Patient navigation and/or the PACT website may improve ACP, including completion of advance care directives and goals of care conversations, in patients with blood cancers who received an HCT.

Conditions

Hematopoietic and Lymphatic System Neoplasm

Study ID

NCT07052630

Start date

Oct 21, 2025

Status verified date

Jun, 2026

Completion date

Oct 31, 2026

Anticipated

Primary completion date

Sep 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Received a transplant for a hematologic malignancy
  • Current age 18 years of age or older
  • Currently 1 to 5 years after HCT
  • Ability to speak and read English
  • Has not completed all advance directives and/or had a goals of care (GOC) conversation with their physician
  • Access to the internet (via computer, tablet, or mobile device)

Exclusion Criteria:

  • Unable to provide informed consent
  • Uncontrolled psychiatric conditions (confirmed through electronic health record \[EHR\] by study staff)

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Factorial

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Condition 1 (PACT, patient navigation)

Patients interact with the PACT website over 4 weeks and receive a navigation session over 45-60 minutes with a trained health coach to review ACP.

experimental: Condition 2 (patient navigation)

Patients receive a navigation session over 45-60 minutes with a trained health coach to review ACP.

experimental: Condition 3 (PACT)

Patients interact with the PACT website over 4 weeks.

active comparator: Condition 4 (standard/usual care)

Patients receive standard/usual care for 4 weeks on study.

Interventions

Internet-Based Intervention

Interact with PACT website

Patient Navigation

Receive a patient navigation session

Best Practice

Receive standard/usual care

Survey Administration

Ancillary studies

Primary outcome measure

  • Feasibility (Rate of enrollment) [ Time Frame: At baseline ]
  • Feasibility (Rate of completion of intervention components) [ Time Frame: At 12 weeks post intervention ]
  • Feasibility (Rate of completion of study assessments) [ Time Frame: At baseline, and at 4 and 12 weeks post intervention ]
  • Acceptability of intervention [ Time Frame: At 4 weeks post intervention ]
  • Completion of advance directives [ Time Frame: At baseline, and at 4 and 12 weeks post intervention ]

Central Contacts and Locations

Central contacts

Locations

Fred Hutch/University of Washington Cancer Consortium

Recruiting

Seattle, Washington, United States, 98109

Contacts

Principal Investigator:

Megan Shen, PhD

More Information

Sponsor

Fred Hutchinson Cancer Center

Last update posted

Jun 5, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Fred Hutchinson Cancer Center on 2026-06-05.