Recruiting

Enamel Matrix Derivatives

Sponsor:

The University of Texas Health Science Center at San Antonio

Code:

NCT07053969

Conditions

Dental Implantation

Missing Teeth

Periodontitis, Adult

Mucositis

Eligibility Criteria

Sex: All

Age: 18

Healthy Volunteers: Accepted

Interventions

Enamel Matrix Derivative

Study Details

Brief summary:

Scientists do research to answer important questions which might help change or improve the way we do things in the future.

The investigators know that using Enamel Matrix Derivatives results in thicker gum tissues around teeth. This study will test to see if using EMD around implants results in thicker gum tissues around implants.

Conditions

Dental Implantation

Missing Teeth

Periodontitis, Adult

Mucositis

Study ID

NCT07053969

Start date

Aug 31, 2025

Status verified date

Nov, 2025

Completion date

Sep, 2027

Anticipated

Primary completion date

Sep, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Ability of subject to understand and the willingness to sign a written informed consent document.
2. Males and females; Age 18 to 89 years old
3. Require second stage implant uncovering
4. In either the maxillary or mandibular arch
5. Has consistent transportation for all clinical and study visits

Exclusion Criteria:

1. Pregnancy, or those planning to become pregnant
2. Allergy or any medical issue using EMD
3. Non-English speaking
4. Patients on anticoagulants
5. Patients who object to the use of animal products

Study Design

Enrollment

32 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Group 1: Experimental Group using EMD

During implant uncovering the experimental group will receive EMD under the buccal flap

no intervention: Group 2: Control Group

No EMD is administered under the buccal flap during suturing

Interventions

Enamel Matrix Derivative

EMD is an FDA approved medical device used in periodontal procedures since 1996. It has been shown to enhance soft and hard tissue healing, increased root coverage and aid in periodontal regeneration. It's use as an adjunct during implant uncovering may increase peri-implant mucosal thickness.

Primary outcome measure

  • Mucosal Thickness [ Time Frame: One month and 3 months ]
  • Change in Keratinized mucosal width [ Time Frame: One month and 3 months ]

Central Contacts and Locations

Central contacts

Angela Palaiologou-Gallis, DDS

210-450-3715PalaiologouA@uthscsa.edu

Locations

University of Texas Health Science Center at San Antonio

Recruiting

San Antonio, Texas, United States, 78229

Contacts

Angela A Palaiologou-Gallis, DDS., MS.

210-567-3567palaiologoua@uthscsa.edu

More Information

Sponsor

The University of Texas Health Science Center at San Antonio

Last update posted

Nov 12, 2025

Last verified

Nov, 2025

Keywords

  • Enamel Matrix Derivatives
  • EMD
  • Keratinized mucosa width
  • Mucosal thickness

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by The University of Texas Health Science Center at San Antonio on 2025-11-12.