Recruiting

Ketone Monoester

Sponsor:

McMaster University

Code:

NCT07063732

Conditions

High Altitude Hypoxia

Exercise

Eligibility Criteria

Sex: All

Age: 18 - 35

Healthy Volunteers: Accepted

Interventions

Ketone Monoester (KME)

Placebo

Study Details

Brief summary:

The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.

Conditions

High Altitude Hypoxia

Exercise

Study ID

NCT07063732

Start date

May 28, 2025

Status verified date

Jul, 2025

Completion date

Aug 31, 2025

Anticipated

Primary completion date

Aug 31, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 35

Healthy Volunteers: Accepted

Inclusion Criteria:

\- Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California

Exclusion Criteria:

  • BMI > 30
  • No prescribed medications (oral contraceptives excluded)
  • History of smoking
  • Currently following a ketogenic diet or consuming exogenous ketogenic supplements
  • History of heart, lung, blood vessel, or kidney disease
  • Currently pregnant

Study Design

Enrollment

14 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: High Altitude (3800m; Barcroft Research Station)

High altitude setting

experimental: Low Altitude (334m; University of Guelph)

Low altitude setting

Interventions

Ketone Monoester (KME)

0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).

Placebo

Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement

Primary outcome measure

  • Cerebral Blood Velocity [ Time Frame: 3 hours ]

Central Contacts and Locations

Locations

Barcroft Research Station

Recruiting

Bishop, California, United States, 93514

Contacts

Jeremy Walsh, PhD

9055259140walshj18@mcmaster.ca

University of Guelph

Recruiting

Guelph, Ontario, Canada, N1G 2W1

Contacts

Jeremy Walsh, PhD

9055259140walshj18@mcmaster.ca

More Information

Sponsor

McMaster University

Last update posted

Jul 14, 2025

Last verified

Jul, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by McMaster University on 2025-07-14.