Recruiting

Optical Coherence Tomography

Sponsor:

Oregon Health and Science University

Code:

NCT07065747

Conditions

Anterior Uveitis (AU)

Birdshot Chorioretinitis

Behcet Disease

Herpes Simplex Virus

Juvenile Idiopathic Arthritis (JIA)

Eligibility Criteria

Sex: All

Age: 5 - 70+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.

Conditions

Anterior Uveitis (AU)

Birdshot Chorioretinitis

Behcet Disease

Herpes Simplex Virus

Juvenile Idiopathic Arthritis (JIA)

Study ID

NCT07065747

Start date

Sep 1, 2024

Status verified date

Jul, 2025

Completion date

Dec, 2026

Anticipated

Primary completion date

Sep, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 5 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.
2. Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).
3. Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.

Exclusion Criteria:

1. Inability to give informed consent.
2. Inability to maintain stable fixation for OCT imaging.
3. Inability to commit to required visits to complete the study.
4. Pregnancy and breastfeeding.

Study Design

Enrollment

125 participants

Anticipated

Interventions and Outcome Measures

Arms

Uveitis Group

Eyes with active inflammation due to various systemic diseases

Posterior Vitreous Detachment Group

Eyes with vitreous floaters and posterior vitreous detachment

Healthy/Control Group

Healthy eyes with no history of uveitis, posterior vitreous detachment, or previous eye surgery

Primary outcome measure

  • Identification & Measurement of Anterior Chamber Cells [ Time Frame: Day 1 ]

Central Contacts and Locations

Central contacts

Humberto Martinez, COT, MBA

503-494-7712martinhu@ohsu.edu

Denzil Romfh, OD

503-494-4351romfhd@ohsu.edu

Locations

Casey Eye Institute - Oregon Health & Science University

Recruiting

Portland, Oregon, United States, 97239

More Information

Sponsor

Oregon Health and Science University

Last update posted

Jul 17, 2025

Last verified

Jul, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-09. This information was provided to ClinicalTrials.gov by Oregon Health and Science University on 2025-07-17. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.