Recruiting
Phase 3

WLE vs. SLN Biopsy

Sponsor:

ECOG-ACRIN Cancer Research Group

Code:

NCT07068074

Conditions

Cutaneous Melanoma

Eligibility Criteria

Sex: All

Age: 70+

Healthy Volunteers: Not accepted

Interventions

Adjuvant Therapy

Comprehensive Geriatric Assessment

Computed Tomography

Positron Emission Tomography

Questionnaire Administration

Study Details

Brief summary:

This phase III trial compares the effect of wide local excision (WLE) alone to usual care with WLE plus sentinel lymph node (SLN) biopsy for the treatment of older adults with early-stage melanoma. A WLE is a surgical procedure performed to cut out an abnormal lesion and some surrounding normal tissue. This is sometimes followed by a SLN biopsy, in which lymph nodes that tumor cells could spread to are removed as well. Using WLE alone may be just as effective as usual care in treating older adults with early-stage melanoma.

Conditions

Cutaneous Melanoma

Study ID

NCT07068074

Start date

Apr 17, 2026

Status verified date

Sep, 2026

Completion date

Jan 1, 2031

Anticipated

Primary completion date

Jan 1, 2031

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient must be ≥ 75 years of age.
  • Patient must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
  • Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible.
  • Patient must have newly diagnosed primary cutaneous melanoma with wide local excision (WLE) and sentinel lymph node (SLN) biopsy indicated per the treating physician, pending definitive surgical management.

  • NOTE: For WLE and SLN to be indicated, the patient must have either:

  • Pathologic features that include ≧ Breslow 0.8 mm OR Breslow < 0.8 mm determined at initial biopsy, with a positive margin, ulceration, lymphovascular invasion, perineural invasion or > 1 mitosis/mm\^2.

OR

  • Risk of SLN metastasis of at least 5%, as calculated using the Melanoma Institute of Australia (MIA) Sentinel Node Metastasis Prediction Tool.

  • Patient must be eligible for WLE and SLN biopsy. Patients for whom SLN biopsy would be contraindicated, difficult to perform (i.e., after prior surgery in the draining basin) or impossible (i.e., after prior lymphadenectomy for another cause) are not eligible.
  • Patient must be eligible for surgery and not have uncontrolled medical condition that in the opinion of the medical or surgical oncologist precludes surgical management.
  • Patient must not have an active infection that precludes enrollment to this study in opinion of treating investigator.
  • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial.
  • Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
  • Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association functional classification. To be eligible for this trial, patients should be class 2B or better.
  • Patient must be English speaking to be eligible for this study in order to complete the patient-reported outcomes (PROs).

  • NOTE: Sites cannot translate the associated quality of life (QOL) forms.

Study Design

Enrollment

428 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Arm A (WLE, SLN biopsy)

Patients undergo WLE plus SLN biopsy and may undergo surveillance of nodal basin as usual care on study. Patients may receive adjuvant therapy as clinically indicated. Additionally, patients may undergo CT, PET/CT or ultrasound throughout the study.

experimental: Arm B (WLE)

Patients undergo WLE and surveillance of nodal basin on study. Patients may receive adjuvant therapy as clinically indicated. Additionally, patients may undergo CT, PET/CT or ultrasound throughout the study.

Interventions

Adjuvant Therapy

Receive adjuvant therapy

Comprehensive Geriatric Assessment

Ancillary studies

Computed Tomography

Undergo CT

Positron Emission Tomography

Undergo PET/CT

Questionnaire Administration

Ancillary studies

Sentinel Lymph Node Biopsy

Undergo SLN biopsy

Surveillance

Undergo surveillance of nodal basin

Ultrasound Imaging

Undergo ultrasound

Wide Local Excision

Undergo WLE

Primary outcome measure

  • Recurrence free survival (RFS) rate [ Time Frame: From randomization to recurrence of disease or death from any cause, assessed at 2 years ]
  • Patient reported outcome (PRO) [ Time Frame: Baseline to 2 years ]

Central Contacts and Locations

Locations

University of Alabama at Birmingham Cancer Center

Recruiting

Birmingham, Alabama, United States, 35233

Contacts

Site Public Contact

gingerreeves@uabmc.edu

Principal Investigator:

Sarah Bateni

Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis

Recruiting

Daphne, Alabama, United States, 36526

Contacts

Principal Investigator:

Udai Sibia

Thomas Hospital

Recruiting

Fairhope, Alabama, United States, 36532

Contacts

Site Public Contact

251-435-4584

Principal Investigator:

Udai Sibia

Mobile Infirmary Medical Center

Recruiting

Mobile, Alabama, United States, 36607

Contacts

Site Public Contact

251-435-3942

Principal Investigator:

Udai Sibia

Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland

Recruiting

Saraland, Alabama, United States, 36571

Contacts

Principal Investigator:

Udai Sibia

Fairbanks Memorial Hospital

Recruiting

Fairbanks, Alaska, United States, 99701

Contacts

Principal Investigator:

John M. Schallenkamp

Cancer Center at Saint Joseph's

Recruiting

Phoenix, Arizona, United States, 85004

Contacts

Principal Investigator:

Shahzad Siddique

Mission Hope Medical Oncology - Arroyo Grande

Recruiting

Arroyo Grande, California, United States, 93420

Contacts

Principal Investigator:

Shahzad Siddique

Mercy Cancer Center - Carmichael

Recruiting

Carmichael, California, United States, 95608

Contacts

Principal Investigator:

Shahzad Siddique

Mercy San Juan Medical Center

Recruiting

Carmichael, California, United States, 95608

Contacts

Principal Investigator:

Shahzad Siddique

Mercy Cancer Center - Elk Grove

Recruiting

Elk Grove, California, United States, 95758

Contacts

Principal Investigator:

Shahzad Siddique

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Recruiting

Irvine, California, United States, 92612

Contacts

Site Public Contact

877-827-8839ucstudy@uci.edu

Principal Investigator:

Thuy Tran

UC San Diego Moores Cancer Center

Recruiting

La Jolla, California, United States, 92093

Contacts

Principal Investigator:

Theresa Guo

Veterans Affairs Loma Linda Healthcare System

Recruiting

Loma Linda, California, United States, 92357

Contacts

Site Public Contact

800-741-8387

Principal Investigator:

Mark E. Reeves

Los Angeles General Medical Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Principal Investigator:

Fumito Ito

USC / Norris Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Site Public Contact

323-865-0451

Principal Investigator:

Fumito Ito

Mercy Cancer Center

Recruiting

Merced, California, United States, 95340

Contacts

Principal Investigator:

Shahzad Siddique

UC Irvine Health/Chao Family Comprehensive Cancer Center

Recruiting

Orange, California, United States, 92868

Contacts

Site Public Contact

877-827-8839ucstudy@uci.edu

Principal Investigator:

Thuy Tran

Mercy Cancer Center - Rocklin

Recruiting

Rocklin, California, United States, 95765

Contacts

Principal Investigator:

Shahzad Siddique

Mercy Cancer Center - Sacramento

Recruiting

Sacramento, California, United States, 95816

Contacts

Principal Investigator:

Shahzad Siddique

Pacific Central Coast Health Center-San Luis Obispo

Recruiting

San Luis Obispo, California, United States, 93401

Contacts

Principal Investigator:

Shahzad Siddique

Mission Hope Medical Oncology - Santa Maria

Recruiting

Santa Maria, California, United States, 93444

Contacts

Principal Investigator:

Shahzad Siddique

Saint Joseph's Medical Center

Recruiting

Stockton, California, United States, 95204

Contacts

Site Public Contact

209-461-5257

Principal Investigator:

Shahzad Siddique

Woodland Memorial Hospital

Recruiting

Woodland, California, United States, 95695

Contacts

Principal Investigator:

Shahzad Siddique

UCHealth University of Colorado Hospital

Recruiting

Aurora, Colorado, United States, 80045

Contacts

Site Public Contact

720-848-0650

Principal Investigator:

Theresa M. Medina

Penrose-Saint Francis Healthcare

Recruiting

Colorado Springs, Colorado, United States, 80907

Contacts

Principal Investigator:

Shahzad Siddique

Rocky Mountain Cancer Centers-Penrose

Recruiting

Colorado Springs, Colorado, United States, 80907

Contacts

Principal Investigator:

Shahzad Siddique

Saint Francis Cancer Center

Recruiting

Colorado Springs, Colorado, United States, 80923

Contacts

Principal Investigator:

Shahzad Siddique

CommonSpirit Cancer Center Mercy

Recruiting

Durango, Colorado, United States, 81301

Contacts

Principal Investigator:

Shahzad Siddique

Mercy Medical Center

Recruiting

Durango, Colorado, United States, 81301

Contacts

Principal Investigator:

Shahzad Siddique

CommonSpirit Saint Anthony Hospital Cancer Center

Recruiting

Lakewood, Colorado, United States, 80228

Contacts

Principal Investigator:

Shahzad Siddique

Longmont United Hospital

Recruiting

Longmont, Colorado, United States, 80501

Contacts

Principal Investigator:

Shahzad Siddique

Saint Mary Corwin Medical Center

Recruiting

Pueblo, Colorado, United States, 81004

Contacts

Principal Investigator:

Shahzad Siddique

Saint Anthony North Hospital

Recruiting

Westminster, Colorado, United States, 80023

Contacts

Principal Investigator:

Shahzad Siddique

Beebe Medical Center

Recruiting

Lewes, Delaware, United States, 19958

Contacts

Principal Investigator:

Gregory A. Masters

Beebe South Coastal Health Campus

Recruiting

Millville, Delaware, United States, 19967

Contacts

Principal Investigator:

Gregory A. Masters

Helen F Graham Cancer Center

Recruiting

Newark, Delaware, United States, 19713

Contacts

Principal Investigator:

Gregory A. Masters

Medical Oncology Hematology Consultants PA

Recruiting

Newark, Delaware, United States, 19713

Contacts

Principal Investigator:

Gregory A. Masters

Christiana Care Health System-Christiana Hospital

Recruiting

Newark, Delaware, United States, 19718

Contacts

Principal Investigator:

Gregory A. Masters

Beebe Health Campus

Recruiting

Rehoboth Beach, Delaware, United States, 19971

Contacts

Principal Investigator:

Gregory A. Masters

Christiana Care Health System-Wilmington Hospital

Recruiting

Wilmington, Delaware, United States, 19801

Contacts

Principal Investigator:

Gregory A. Masters

Orlando Health Cancer Institute - Lake Mary

Recruiting

Lake Mary, Florida, United States, 32746

Contacts

Principal Investigator:

Rajesh M. Nair

Lakeland Regional Health Hollis Cancer Center

Recruiting

Lakeland, Florida, United States, 33805

Contacts

Site Public Contact

863-904-1900

Principal Investigator:

Manuel A. Molina-Vega

Health Central

Recruiting

Ocoee, Florida, United States, 34761

Contacts

Principal Investigator:

Rajesh M. Nair

Orlando Health Cancer Institute

Recruiting

Orlando, Florida, United States, 32806

Contacts

Principal Investigator:

Rajesh M. Nair

Emory University Hospital/Winship Cancer Institute

Recruiting

Atlanta, Georgia, United States, 30322

Contacts

Site Public Contact

404-778-1868

Principal Investigator:

Michael Lowe

Emory Saint Joseph's Hospital

Recruiting

Atlanta, Georgia, United States, 30342

Contacts

Site Public Contact

404-851-7115

Principal Investigator:

Michael Lowe

Kootenai Health - Coeur d'Alene

Recruiting

Coeur d'Alene, Idaho, United States, 83814

Contacts

Principal Investigator:

John M. Schallenkamp

Kootenai Clinic Cancer Services - Post Falls

Recruiting

Post Falls, Idaho, United States, 83854

Contacts

Principal Investigator:

John M. Schallenkamp

Kootenai Clinic Cancer Services - Sandpoint

Recruiting

Sandpoint, Idaho, United States, 83864

Contacts

Principal Investigator:

John M. Schallenkamp

Loyola Center for Health at Burr Ridge

Recruiting

Burr Ridge, Illinois, United States, 60527

Contacts

Site Public Contact

708-216-9000

Principal Investigator:

Joseph I. Clark

Northwestern University

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Principal Investigator:

Jeffrey D. Wayne

Swedish Covenant Hospital

Recruiting

Chicago, Illinois, United States, 60625

Contacts

Site Public Contact

773-878-8200

Principal Investigator:

Dhruv Bansal

NorthShore University HealthSystem-Evanston Hospital

Recruiting

Evanston, Illinois, United States, 60201

Contacts

Site Public Contact

847-570-2109

Principal Investigator:

Dhruv Bansal

NorthShore University HealthSystem-Glenbrook Hospital

Recruiting

Glenview, Illinois, United States, 60026

Contacts

Site Public Contact

847-570-2109

Principal Investigator:

Dhruv Bansal

NorthShore University HealthSystem-Highland Park Hospital

Recruiting

Highland Park, Illinois, United States, 60035

Contacts

Site Public Contact

847-570-2109

Principal Investigator:

Dhruv Bansal

Loyola Medicine Homer Glen

Recruiting

Homer Glen, Illinois, United States, 60491

Contacts

Site Public Contact

708-216-9000

Principal Investigator:

Joseph I. Clark

Northwestern Medicine Lake Forest Hospital

Recruiting

Lake Forest, Illinois, United States, 60045

Contacts

Principal Investigator:

Jeffrey D. Wayne

Loyola University Medical Center

Recruiting

Maywood, Illinois, United States, 60153

Contacts

Site Public Contact

708-226-4357

Principal Investigator:

Joseph I. Clark

Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Recruiting

Melrose Park, Illinois, United States, 60160

Contacts

Site Public Contact

708-450-4554

Principal Investigator:

Joseph I. Clark

Northwestern Medicine Orland Park

Recruiting

Orland Park, Illinois, United States, 60462

Contacts

Principal Investigator:

Jeffrey D. Wayne

University of Kansas Cancer Center

Recruiting

Kansas City, Kansas, United States, 66160

Contacts

Principal Investigator:

Luke V. Selby

University of Kansas Cancer Center-Overland Park

Recruiting

Overland Park, Kansas, United States, 66210

Contacts

Principal Investigator:

Luke V. Selby

University of Kansas Hospital-Indian Creek Campus

Recruiting

Overland Park, Kansas, United States, 66211

Contacts

Principal Investigator:

Luke V. Selby

University of Kansas Hospital-Westwood Cancer Center

Recruiting

Westwood, Kansas, United States, 66205

Contacts

Principal Investigator:

Luke V. Selby

CommonSpirit Saint Joseph Hospital - Bardstown

Recruiting

Bardstown, Kentucky, United States, 40004

Contacts

Principal Investigator:

Shahzad Siddique

Commonwealth Cancer Center-Corbin

Recruiting

Corbin, Kentucky, United States, 40701

Contacts

Principal Investigator:

Shahzad Siddique

CommonSpirit Saint Joseph Hospital - Lexington

Recruiting

Lexington, Kentucky, United States, 40504

Contacts

Principal Investigator:

Shahzad Siddique

Saint Joseph Radiation Oncology Resource Center

Recruiting

Lexington, Kentucky, United States, 40504

Contacts

Principal Investigator:

Shahzad Siddique

CommonSpirit Saint Joseph Medical Center - East Lexington

Recruiting

Lexington, Kentucky, United States, 40509

Contacts

Principal Investigator:

Shahzad Siddique

University of Kentucky/Markey Cancer Center

Recruiting

Lexington, Kentucky, United States, 40536

Contacts

Site Public Contact

859-257-3379

Principal Investigator:

Irada Ibrahim-Zada

CommonSpirit Saint Joseph Hospital London

Recruiting

London, Kentucky, United States, 40741

Contacts

Principal Investigator:

Shahzad Siddique

CommonSpirit Saint Joseph Hospital Mount Sterling

Recruiting

Mount Sterling, Kentucky, United States, 40353

Contacts

Principal Investigator:

Shahzad Siddique

LSU Health Baton Rouge-North Clinic

Recruiting

Baton Rouge, Louisiana, United States, 70805

Contacts

Principal Investigator:

Sagar G. Kansara

Our Lady of the Lake Physician Group

Recruiting

Baton Rouge, Louisiana, United States, 70808

Contacts

Principal Investigator:

Sagar G. Kansara

Christiana Care - Union Hospital

Recruiting

Elkton, Maryland, United States, 21921

Contacts

Principal Investigator:

Gregory A. Masters

Bronson Battle Creek

Recruiting

Battle Creek, Michigan, United States, 49017

Contacts

Principal Investigator:

Kathleen Y. Butler

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Recruiting

Grand Rapids, Michigan, United States, 49503

Contacts

Principal Investigator:

Kathleen Y. Butler

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Recruiting

Grand Rapids, Michigan, United States, 49503

Contacts

Principal Investigator:

Kathleen Y. Butler

Bronson Methodist Hospital

Recruiting

Kalamazoo, Michigan, United States, 49007

Contacts

Principal Investigator:

Kathleen Y. Butler

West Michigan Cancer Center

Recruiting

Kalamazoo, Michigan, United States, 49007

Contacts

Principal Investigator:

Kathleen Y. Butler

Corewell Health Lakeland Hospitals - Niles Hospital

Recruiting

Niles, Michigan, United States, 49120

Contacts

Site Public Contact

616-391-1230

Principal Investigator:

Kathleen Y. Butler

Corewell Health Reed City Hospital

Recruiting

Reed City, Michigan, United States, 49677

Contacts

Principal Investigator:

Kathleen Y. Butler

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Recruiting

Saint Joseph, Michigan, United States, 49085

Contacts

Principal Investigator:

Kathleen Y. Butler

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Recruiting

Saint Joseph, Michigan, United States, 49085

Contacts

Principal Investigator:

Kathleen Y. Butler

Munson Medical Center

Recruiting

Traverse City, Michigan, United States, 49684

Contacts

Principal Investigator:

Kathleen Y. Butler

University of Michigan Health - West

Recruiting

Wyoming, Michigan, United States, 49519

Contacts

Principal Investigator:

Kathleen Y. Butler

Sanford Joe Lueken Cancer Center

Recruiting

Bemidji, Minnesota, United States, 56601

Contacts

Principal Investigator:

Daniel Almquist

Sanford Thief River Falls Medical Center

Recruiting

Thief River Falls, Minnesota, United States, 56701

Contacts

Site Public Contact

605-312-3320

Principal Investigator:

Daniel Almquist

University of Kansas Cancer Center - Briarcliff

Recruiting

Kansas City, Missouri, United States, 64116

Contacts

Site Public Contact

913-588-3671

Principal Investigator:

Luke V. Selby

University of Kansas Cancer Center - North

Recruiting

Kansas City, Missouri, United States, 64154

Contacts

Principal Investigator:

Luke V. Selby

University of Kansas Cancer Center - Lee's Summit

Recruiting

Lee's Summit, Missouri, United States, 64064

Contacts

Principal Investigator:

Luke V. Selby

Community Hospital of Anaconda

Recruiting

Anaconda, Montana, United States, 59711

Contacts

Principal Investigator:

John M. Schallenkamp

Billings Clinic Cancer Center

Recruiting

Billings, Montana, United States, 59101

Contacts

Principal Investigator:

John M. Schallenkamp

Bozeman Health Deaconess Hospital

Recruiting

Bozeman, Montana, United States, 59715

Contacts

Principal Investigator:

John M. Schallenkamp

Benefis Sletten Cancer Institute

Recruiting

Great Falls, Montana, United States, 59405

Contacts

Principal Investigator:

John M. Schallenkamp

Great Falls Clinic

Recruiting

Great Falls, Montana, United States, 59405

Contacts

Principal Investigator:

John M. Schallenkamp

Hi-Line Sletten Cancer Center

Recruiting

Havre, Montana, United States, 59501

Contacts

Site Public Contact

ecog.rss@jimmy.harvard.edu

Principal Investigator:

John M. Schallenkamp

Benefis Helena Specialty Center

Recruiting

Helena, Montana, United States, 59601

Contacts

Principal Investigator:

John M. Schallenkamp

Logan Health Medical Center

Recruiting

Kalispell, Montana, United States, 59901

Contacts

Principal Investigator:

John M. Schallenkamp

Community Medical Center

Recruiting

Missoula, Montana, United States, 59804

Contacts

Principal Investigator:

John M. Schallenkamp

CHI Health Saint Francis

Recruiting

Grand Island, Nebraska, United States, 68803

Contacts

Principal Investigator:

Shahzad Siddique

CHI Health Good Samaritan

Recruiting

Kearney, Nebraska, United States, 68847

Contacts

Principal Investigator:

Shahzad Siddique

Alegent Health Immanuel Medical Center

Recruiting

Omaha, Nebraska, United States, 68122

Contacts

Principal Investigator:

Shahzad Siddique

Alegent Health Bergan Mercy Medical Center

Recruiting

Omaha, Nebraska, United States, 68124

Contacts

Principal Investigator:

Shahzad Siddique

Alegent Health Lakeside Hospital

Recruiting

Omaha, Nebraska, United States, 68130

Contacts

Principal Investigator:

Shahzad Siddique

Renown Regional Medical Center

Recruiting

Reno, Nevada, United States, 89502

Contacts

Principal Investigator:

Alicia Gingrich

Hackensack University Medical Center

Recruiting

Hackensack, New Jersey, United States, 07601

Contacts

Site Public Contact

551-996-2897

Principal Investigator:

Andrew L. Pecora

Hackettstown Medical Center

Recruiting

Hackettstown, New Jersey, United States, 07840

Contacts

Site Public Contact

973-971-5990

Principal Investigator:

Eric D. Whitman

Monmouth Medical Center

Recruiting

Long Branch, New Jersey, United States, 07740

Contacts

Principal Investigator:

Jessica A. Cintolo-Gonzalez

Morristown Medical Center

Recruiting

Morristown, New Jersey, United States, 07960

Contacts

Site Public Contact

973-971-5900

Principal Investigator:

Eric D. Whitman

Rutgers Cancer Institute of New Jersey

Recruiting

New Brunswick, New Jersey, United States, 08903

Contacts

Site Public Contact

732-235-7356

Principal Investigator:

Jessica A. Cintolo-Gonzalez

Newton Medical Center

Recruiting

Newton, New Jersey, United States, 07860

Contacts

Site Public Contact

973-971-5990

Principal Investigator:

Eric D. Whitman

John Theurer Cancer Center at From Road

Recruiting

Paramus, New Jersey, United States, 07652

Contacts

Site Public Contact

551-996-2897

Principal Investigator:

Andrew L. Pecora

Chilton Medical Center

Recruiting

Pompton, New Jersey, United States, 07444

Contacts

Site Public Contact

973-971-5990

Principal Investigator:

Eric D. Whitman

Overlook Hospital

Recruiting

Summit, New Jersey, United States, 07902

Contacts

Site Public Contact

908-522-2043

Principal Investigator:

Eric D. Whitman

Community Medical Center

Recruiting

Toms River, New Jersey, United States, 08755

Contacts

Principal Investigator:

Jessica A. Cintolo-Gonzalez

University of New Mexico Cancer Center

Recruiting

Albuquerque, New Mexico, United States, 87106

Contacts

Principal Investigator:

David Savage

Lovelace Women's Hospital

Recruiting

Albuquerque, New Mexico, United States, 87109

Contacts

Site Public Contact

505-272-0530AYost@nmcca.org

Principal Investigator:

David Savage

Roswell Park Cancer Institute

Recruiting

Buffalo, New York, United States, 14263

Contacts

Principal Investigator:

Eleanor A. Fallon

Glens Falls Hospital

Recruiting

Glens Falls, New York, United States, 12801

Contacts

Site Public Contact

518-926-6700

Principal Investigator:

Conor H. O'Neill

NYU Langone Hospital - Long Island

Recruiting

Mineola, New York, United States, 11501

Contacts

Principal Investigator:

Erica B. Friedman

Laura and Isaac Perlmutter Cancer Center at NYU Langone

Recruiting

New York, New York, United States, 10016

Contacts

Site Public Contact

CancerTrials@nyulangone.org

Principal Investigator:

Erica B. Friedman

NYU Langone Hospital - Suffolk

Recruiting

Patchogue, New York, United States, 11772

Contacts

Site Public Contact

cancertrials@nyulangone.org

Principal Investigator:

Erica B. Friedman

Stony Brook University Medical Center

Recruiting

Stony Brook, New York, United States, 11794

Contacts

Site Public Contact

800-862-2215

Principal Investigator:

Tara Huston

Montefiore Medical Center-Einstein Campus

Recruiting

The Bronx, New York, United States, 10461

Contacts

Principal Investigator:

Yvonne Saenger

Duke Cancer Center Cary

Recruiting

Cary, North Carolina, United States, 27518

Contacts

Site Public Contact

NCTNStudyTeam@dm.duke.edu

Principal Investigator:

Jay S. Lee

Duke University Medical Center

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Site Public Contact

888-275-3853

Principal Investigator:

Jay S. Lee

Duke Cancer Center Raleigh

Recruiting

Raleigh, North Carolina, United States, 27609

Contacts

Site Public Contact

NCTNStudyTeam@dm.duke.edu

Principal Investigator:

Jay S. Lee

Sanford Bismarck Medical Center

Recruiting

Bismarck, North Dakota, United States, 58501

Contacts

Principal Investigator:

Daniel Almquist

Sanford South University Medical Center

Recruiting

Fargo, North Dakota, United States, 58103

Contacts

Site Public Contact

701-234-6161

Principal Investigator:

Daniel Almquist

Southpointe-Sanford Medical Center Fargo

Recruiting

Fargo, North Dakota, United States, 58103

Contacts

Site Public Contact

605-312-3320

Principal Investigator:

Daniel Almquist

Sanford Medical Center Fargo

Recruiting

Fargo, North Dakota, United States, 58104

Contacts

Site Public Contact

800-437-4010

Principal Investigator:

Daniel Almquist

Sanford Broadway Medical Center

Recruiting

Fargo, North Dakota, United States, 58122

Contacts

Principal Investigator:

Daniel Almquist

Sanford Roger Maris Cancer Center

Recruiting

Fargo, North Dakota, United States, 58122

Contacts

Principal Investigator:

Daniel Almquist

UH Seidman Cancer Center at UH Avon Health Center

Recruiting

Avon, Ohio, United States, 44011

Contacts

Site Public Contact

800-641-2422

Principal Investigator:

Luke D. Rothermel

UHHS-Chagrin Highlands Medical Center

Recruiting

Beachwood, Ohio, United States, 44122

Contacts

Principal Investigator:

Luke D. Rothermel

Good Samaritan Hospital - Cincinnati

Recruiting

Cincinnati, Ohio, United States, 45220

Contacts

Principal Investigator:

Shahzad Siddique

Bethesda North Hospital

Recruiting

Cincinnati, Ohio, United States, 45242

Contacts

Principal Investigator:

Shahzad Siddique

TriHealth Cancer Institute-Westside

Recruiting

Cincinnati, Ohio, United States, 45247

Contacts

Principal Investigator:

Shahzad Siddique

TriHealth Cancer Institute-Anderson

Recruiting

Cincinnati, Ohio, United States, 45255

Contacts

Principal Investigator:

Shahzad Siddique

Case Western Reserve University

Recruiting

Cleveland, Ohio, United States, 44106

Contacts

Principal Investigator:

Luke D. Rothermel

Ohio State University Comprehensive Cancer Center

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Principal Investigator:

Joal Beane

University of Oklahoma Health Sciences Center

Recruiting

Oklahoma City, Oklahoma, United States, 73104

Contacts

Principal Investigator:

Ajay Jain

Christiana Care Health System-Concord Health Center

Recruiting

Chadds Ford, Pennsylvania, United States, 19317

Contacts

Principal Investigator:

Gregory A. Masters

Fox Chase Cancer Center - East Norriton Hospital Outpatient Center

Recruiting

East Norriton, Pennsylvania, United States, 19401

Contacts

Site Public Contact

ecog.rss@jimmy.harvard.edu

Principal Investigator:

Maureen Hill

UPMC Hillman Cancer Center Erie

Recruiting

Erie, Pennsylvania, United States, 16505

Contacts

Principal Investigator:

Yana Najjar

Thomas Jefferson University Hospital

Recruiting

Philadelphia, Pennsylvania, United States, 19107

Contacts

Principal Investigator:

Rino Seedor

Fox Chase Cancer Center

Recruiting

Philadelphia, Pennsylvania, United States, 19111

Contacts

Site Public Contact

215-728-4790

Principal Investigator:

Maureen Hill

UPMC Hillman Cancer Center

Recruiting

Pittsburgh, Pennsylvania, United States, 15232

Contacts

Site Public Contact

412-647-8073

Principal Investigator:

Yana Najjar

Asplundh Cancer Pavilion

Recruiting

Willow Grove, Pennsylvania, United States, 19090

Contacts

Principal Investigator:

Rino Seedor

Medical University of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Principal Investigator:

Andrea M. Abbott

Vanderbilt University/Ingram Cancer Center

Recruiting

Nashville, Tennessee, United States, 37232

Contacts

Site Public Contact

800-811-8480

Principal Investigator:

Cameron E. Schlegel

Central Vermont Medical Center/National Life Cancer Treatment

Recruiting

Berlin Corners, Vermont, United States, 05602

Contacts

Site Public Contact

802-225-5400

Principal Investigator:

Conor H. O'Neill

University of Vermont Medical Center

Recruiting

Burlington, Vermont, United States, 05401

Contacts

Site Public Contact

802-656-4101rpo@uvm.edu

Principal Investigator:

Conor H. O'Neill

University of Vermont and State Agricultural College

Recruiting

Burlington, Vermont, United States, 05405

Contacts

Site Public Contact

802-656-8990rpo@uvm.edu

Principal Investigator:

Conor H. O'Neill

University of Virginia Cancer Center

Recruiting

Charlottesville, Virginia, United States, 22908

Contacts

Principal Investigator:

Lynn T. Dengel

VCU Massey Cancer Center at Stony Point

Recruiting

Richmond, Virginia, United States, 23235

Contacts

Site Public Contact

ctoclinops@vcu.edu

Principal Investigator:

Benjamin Schmidt

VCU Massey Comprehensive Cancer Center

Recruiting

Richmond, Virginia, United States, 23298

Contacts

Principal Investigator:

Benjamin Schmidt

Fred Hutchinson Cancer Center

Recruiting

Seattle, Washington, United States, 98109

Contacts

Site Public Contact

800-804-8824

Principal Investigator:

Katherine Jackson

University of Washington Medical Center - Montlake

Recruiting

Seattle, Washington, United States, 98195

Contacts

Site Public Contact

800-804-8824

Principal Investigator:

Katherine Jackson

Saint Joseph Medical Center Hematology and Oncology - Silverdale

Recruiting

Silverdale, Washington, United States, 98383

Contacts

Principal Investigator:

Shahzad Siddique

United Hospital Center

Recruiting

Bridgeport, West Virginia, United States, 26330

Contacts

Principal Investigator:

Joanna A. Kolodney

WVUH-Berkely Medical Center

Recruiting

Martinsburg, West Virginia, United States, 25401

Contacts

Principal Investigator:

Joanna A. Kolodney

West Virginia University Healthcare

Recruiting

Morgantown, West Virginia, United States, 26506

Contacts

Principal Investigator:

Joanna A. Kolodney

Camden Clark Medical Center

Recruiting

Parkersburg, West Virginia, United States, 26101

Contacts

Principal Investigator:

Joanna A. Kolodney

Princeton Community Hospital

Recruiting

Princeton, West Virginia, United States, 24740

Contacts

Site Public Contact

304-487-7515

Principal Investigator:

Joanna A. Kolodney

Marshfield Medical Center-Marshfield

Recruiting

Marshfield, Wisconsin, United States, 54449

Contacts

Principal Investigator:

Rohit Sharma

Froedtert Menomonee Falls Hospital

Recruiting

Menomonee Falls, Wisconsin, United States, 53051

Contacts

Site Public Contact

262-257-5100

Principal Investigator:

Callisia N. Clarke

Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Site Public Contact

414-805-3666

Principal Investigator:

Callisia N. Clarke

Froedtert and MCW Moorland Reserve Health Center

Recruiting

New Berlin, Wisconsin, United States, 53151

Contacts

Site Public Contact

414-805-0505

Principal Investigator:

Callisia N. Clarke

Drexel Town Square Health Center

Recruiting

Oak Creek, Wisconsin, United States, 53154

Contacts

Site Public Contact

414-805-0505

Principal Investigator:

Callisia N. Clarke

Froedtert West Bend Hospital/Kraemer Cancer Center

Recruiting

West Bend, Wisconsin, United States, 53095

Contacts

Site Public Contact

414-805-0505

Principal Investigator:

Callisia N. Clarke

Marshfield Medical Center - Weston

Recruiting

Weston, Wisconsin, United States, 54476

Contacts

Principal Investigator:

Rohit Sharma

Memorial Hospital of Laramie County

Recruiting

Cheyenne, Wyoming, United States, 82001

Contacts

Site Public Contact

ecog.rss@jimmy.harvard.edu

Principal Investigator:

John M. Schallenkamp

Billings Clinic-Cody

Recruiting

Cody, Wyoming, United States, 82414

Contacts

Principal Investigator:

John M. Schallenkamp

More Information

Sponsor

ECOG-ACRIN Cancer Research Group

Last update posted

Sep 24, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-25. This information was provided to ClinicalTrials.gov by ECOG-ACRIN Cancer Research Group on 2026-09-24. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.