Recruiting

CBD

Sponsor:

University of Minnesota

Code:

NCT07069478

Conditions

CBD

Cannabidiol

Stress

Acute Stress Reaction

Eligibility Criteria

Sex: All

Age: 21 - 70

Healthy Volunteers: Accepted

Interventions

Stress Intervention

Study Details

Brief summary:

The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.

Conditions

CBD

Cannabidiol

Stress

Acute Stress Reaction

Study ID

NCT07069478

Start date

Jun 16, 2025

Status verified date

Jul, 2026

Completion date

Dec 31, 2028

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 70

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adults who are relatively healthy and aged 21-70 years.
  • Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
  • Must either (1) use CBD daily/regularly or (2) not use CBD regularly.

Exclusion Criteria:

  • Participated in previous acute stress studies that included a similar stress induction.
  • Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
  • Self-reported current pregnancy.
  • Self-reported current use of illicit substances (other than cannabis).
  • Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
  • Students of the principal researcher

Study Design

Enrollment

125 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Experimental group

Participants will include CBD users and non users

Interventions

Stress Intervention

Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds.

Primary outcome measure

  • Change in subjective states (stress, anxiety, positive affect) [ Time Frame: 2.5 hours ]
  • Change in cardiovascular activity and cortisol [ Time Frame: 2.5 hours ]

Central Contacts and Locations

Central contacts

Stress and Resilience Research Labs

2187268623umdbml@d.umn.edu

Locations

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Stress and Resilience Research Labs

218-726-8623umdbml@d.umn.edu

More Information

Sponsor

University of Minnesota

Last update posted

Jul 22, 2026

Last verified

Jul, 2026

Keywords

  • cardiovascular reactivity, , , ,
  • hypothalamic-pituitary-adrenal axis
  • stress
  • mood
  • CBD use

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-07-22.