Recruiting

Phase 1

ICI & SBRTIpilimumab and Nivolumab With SBRT in Locally Advanced Hepatocellular Cancer

Sponsor:

University of Hawaii

Code:

NCT07075120

Conditions

Hepatocellular Carcinoma (HCC)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Ipilimumab and Nivolumab

Stereotactic Body Radiotherapy (SBRT)

Study Details

Brief summary:

Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally, with Native Hawaiian and Pacific Islander (NHPI) populations experiencing significantly higher mortality rates compared to other groups in Hawaii. This disparity is influenced by factors such as higher prevalence of chronic hepatitis B, non-alcoholic fatty liver disease, limited access to early detection, and delayed diagnoses. NHPI patients are also underrepresented in clinical trials, limiting the relevance of treatment advances for this population.

The standard treatment for HCC is surgical resection; however, many NHPI patients present with unresectable disease. Recent advances with immune checkpoint inhibitors (ICIs), such as nivolumab and ipilimumab, have shown promise in treating advanced HCC and improving survival in previously untreatable cases. Additionally, stereotactic body radiotherapy (SBRT) has been shown to enhance survival and local control when combined with systemic therapies like ICIs. However, without surgery, outcomes remain suboptimal, with response rates for ICIs alone at 20-30%, and combination ICI-SBRT treatment showing slightly better results but still a high risk of progression.

Despite improvements in HCC treatment, significant gaps remain in managing borderline resectable disease, especially in NHPI patients. This study aims to evaluate the safety and efficacy of combining ICIs and SBRT with curative surgery for patients with borderline resectable HCC, focusing on NHPI populations. The study will also explore the use of biomarkers such as cell-free DNA (cfDNA), CD8+ T-cell infiltration, and serum cytokine markers to guide personalized treatment strategies. Preliminary findings suggest that this multimodal approach may improve outcomes and enable surgical resection for patients previously considered inoperable.

This study seeks to address the unmet need for effective treatment strategies in borderline resectable HCC and to improve survival outcomes for underserved NHPI populations.

Conditions

Hepatocellular Carcinoma (HCC)

Study ID

NCT07075120

Start date

Apr 1, 2026

Status verified date

Apr, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Aug 1, 2027

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Main Criteria for Inclusion/Exclusion

Inclusion Criteria:

Histologically or cytologically confirmed hepatocellular cancer
Locally advanced/borderline resectable HCC as defined by:

Solitary tumor >5 cm, OR
Unilobar multifocal disease either with >3 tumors or one tumor >3 cm, OR
Bilobar disease with adequate future liver remnant, still technically resectable, OR
High risk disease features (tumor >3 cm with macrovascular invasion or tumor >3 cm with AFP>400).
No extrahepatic spread, no nodal disease, no bilateral left and right branch portal vein involvement, no hepatic vein / IVC involvement. Unilateral hepatic vein involvement is not exclusionary.
Measurable disease per RECIST 1.1 as determined by the investigator
Age ≥ 18 years old on the day of consent
ECOG performance status ≤1 (Appendix XX)
Adequate organ and marrow function, as defined below. Criteria "a," "b," "c," and "f" cannot be met with transfusions, infusions, or growth factor support administered within 14 days of starting the first dose.

Hemoglobin ≥9 g/dL
Absolute neutrophil count ≥1000/μL
Platelet count ≥90,000/μL
Total bilirubin (TBL) <2.0 mg/dL
ASTandALT≤5×ULN
Albumin≥2.8g/dL
International normalized ratio(INR)≤2xULN
Calculated creatinine clearance ≥ 40 mL/minute as determined by Cockcroft-Gault (using actual body weight) or 24-hour urine creatinine clearance
Exclusion Criteria:

Prior systemic therapy for hepatocellular carcinoma
Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of radiation within 28 days of the first dose of study drug(s).
Ascites that requires ongoing paracentesis, within 6 weeks prior to the first scheduled dose, to control symptoms.
Active or prior documented GI variceal bleed or history of upper GI bleeding, ulcers, or esophageal varices with bleeding within 60 days prior to registration; adequate endoscopic therapy according to institutional standards is required for patients with history of esophageal variceal bleeding or assessed as high risk for esophageal variceal by the treating investigator.
Hepatic encephalopathy within 12 months of trial registration
Patient currently exhibits symptomatic or uncontrolled hypertension defined as diastolic blood pressure >90 mmHg or systolic blood pressure >140 mmHg.
Prior external beam radiation therapy to the liver, prior yttrium-90 radioembolization
HBV viral load >100 IU/mL, ongoing corticosteroid therapy >10 mg prednisone daily, and active autoimmune disease requiring systemic therapy in the past 2 years.
Direct tumor extension into stomach, duodenum, small or large bowel
Active or untreated central nervous system (CNS) and leptomeningeal metastases
History of another primary malignancy except for:

Malignancy treated with curative intentand with no known active disease ≥ 5years before the first dose of study drug(s) and of low potential risk for recurrence
Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease
Adequately treated carcinoma in situ without evidence of disease
Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC.
Active infection including tuberculosis (TB) (clinical evaluation that includes clinical history, physical examination and radiographic findings, and TB testing in line with local practice), or human immunodeficiency virus (positive human HIV 1/2 antibodies).

Study Design

Enrollment

15 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Ipilimumab and Nivolumab with SBRT and Surgical Resection

Arm A: Patients receive ipilimumab 3mg/kg and nivolumab 1mg/kg for nine weeks (three cycles). Following completion of preoperative immunotherapy, imaging with CT or MRI is performed to determine resectability. Eligible patients proceed to surgical resection.

Arm B: Patients who are not eligible for resection continue immunotherapy (ipilimumab and nivolumab) for one additional cycle, then nivolumab 480mg every four weeks combined with stereotactic body radiotherapy (SBRT). SBRT is administered in 3-5 fractions, and patients continue imaging every nine weeks. Surgical resection is performed once resectability is confirmed.

Interventions

Ipilimumab and Nivolumab

Immunotherapy combination (Ipilimumab and Nivolumab) targeting CTLA-4 and PD-1 pathways to enhance immune response.

Stereotactic Body Radiotherapy (SBRT)

High-dose radiation therapy delivered in 3-5 fractions for local control of tumors in combination with immunotherapy. Radiation dosages are based on the RTOG 1112 trial guidelines to minimize normal tissue exposure.

Primary outcome measure

Feasibility of Treatment Regimen [ Time Frame: From treatment initiation to surgery completion (up to 12 months) ]
R0 Resection Rate [ Time Frame: From treatment initiation to surgery (up to 12 weeks) ]

Central Contacts and Locations

Central contacts

Jared D Acoba, MD

8085318521 jacoba@hawaii.edu

Tomomi Otaki

8084404583 iit@cc.hawaii.edu

Locations

The Queen's Medical Center

Recruiting

Honolulu, Hawaii, United States, 96813

Contacts

Jared Acoba, MD

808-531-8521 jacoba@cc.hawaii.edu

More Information

Sponsor

University of Hawaii

Last update posted

Apr 30, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Hawaii on 2026-04-30.