Recruiting
Phase 3

Epidural Medication

Sponsor:

UCLA

Code:

NCT07076368

Conditions

Pregnancy

Labor and Delivery

Labor Analgesia

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Ropivacaine + Fentanyl

Study Details

Brief summary:

This study is being done to determine the most effective dose of medicine to use to initially provide effective pain relief within the first 30 minutes of receiving an epidural for pain labor during labor. The study team will also study any side effects related to the epidural medication and patients' satisfaction with the quality of pain relief after receiving the epidural.

Conditions

Pregnancy

Labor and Delivery

Labor Analgesia

Study ID

NCT07076368

Start date

Oct 24, 2025

Status verified date

Jan, 2026

Completion date

Jul 31, 2026

Anticipated

Primary completion date

Jul 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients with singleton vertex pregnancies in active labor (latent or spontaneous labor or after induction of labor)
  • Cervical dilatation between 2 and 7 cm
  • Requesting neuraxial labor analgesia
  • Age 18 or older

Exclusion Criteria:

  • Significant obstetric disease (e.g., pre-eclampsia, major cardiac disease)
  • Chronic pain or chronic opioid use
  • BMI ≥ 50
  • Multiple gestations
  • Allergy or anaphylaxis to local anesthetic
  • Fetal compromise or non-reassuring fetal trace
  • Age under 18
  • Inability to speak and understand English or Spanish

Study Design

Enrollment

50 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Observational Cohort

Patients with singleton vertex pregnancies in active labor (spontaneous or after induction of labor), with a cervical dilatation between 1 and 7cm who are requesting neuraxial labor analgesia, Age =>18 yrs

Interventions

Ropivacaine + Fentanyl

A standard epidural admixture - 0.1% Ropivacaine + 2 mcg/ml fentanyl - will be used.

Primary outcome measure

  • Numerical Pain score [ Time Frame: 30 mins post-intervention ]

Central Contacts and Locations

Central contacts

Alexander Butwick, MBBS, FRCA, MS

415-514-3757alexander.butwick@ucsf.edu

Locations

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94158

Contacts

Alexander Butwick

415-514-3757alexander.butwick@ucsf.edu

More Information

Sponsor

University of California, San Francisco

Last update posted

Jan 27, 2026

Last verified

Jan, 2026

Keywords

  • epidural
  • labor analgesia
  • pregnancy
  • obstetric anesthesia

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-01-27.