Recruiting

Wavefront vs. Ray Tracing

Sponsor:

Stanford University

Code:

NCT07078799

Conditions

Myopia

Astigmatism

Eligibility Criteria

Sex: All

Age: 22 - 59

Healthy Volunteers: Accepted

Interventions

LASIK

LASIK

Study Details

Brief summary:

We are enrolling participants aged 22 and older to have LASIK surgery in both eyes. We will perform wavefront-guided LASIK in one eye and ray tracing-guided LASIK in the fellow eye of each participant. We are trying to see if there are any differences in the efficacy between the two types of LASIK procedures.

Conditions

Myopia

Astigmatism

Study ID

NCT07078799

Start date

Jan 20, 2026

Status verified date

Jan, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 22 - 59

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Age 22 and older
2. People with healthy eyes:

1. No abnormal corneal shape
2. No excessively thin corneas
3. No eye diseases such as glaucoma or cataracts
3. Nearsightedness between -1.00 diopters and -10.00 diopters.
4. Subjects with less than or equal to 3.00 diopters of astigmatism.
5. Subjects must have similar levels of nearsightedness in each eye.

Exclusion Criteria:

1. Subjects under the age of 22.
2. Subjects with excessively thin corneas.
3. Subjects with topographic evidence of keratoconus.
4. Subjects with ectactic eye disorders.
5. Subjects with autoimmune diseases.
6. Subjects who are pregnant or nursing at the time of surgery. (The FDA-approved labelling indications for LASIK specifically excludes patients who are pregnant or nursing. There is no strict prohibition not to become pregnant during the one year study period)
7. They can not be more than 1.5 diopter of difference between eyes.
8. Subjects with more than 3.00 diopters of astigmatism
9. Subjects with disimilar levels of astigmatism in each eye (They can not have more than 0.75 diopters of difference between eyes) -

Study Design

Enrollment

70 participants

Anticipated

Allocation

Randomized

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Wavefront-guided laser ablation

Wavefront-guided LASIK

active comparator: Ray tracing-guided LASIK

Ray-tracing guided LASIK is being performed in one eye and Wavefront-guided LASIK is being performed in the fellow eye

Interventions

LASIK

Wavefront-guided LASIK is being performed in one eye and Ray-tracing guided LASIK is being performed in the fellow eye

LASIK

Ray-tracing guided LASIK is being performed in one eye and Wavefront-guided LASIK is being performed in the fellow eye.

Primary outcome measure

  • Uncorrected visual acuity [ Time Frame: One year ]

Central Contacts and Locations

Central contacts

Edward E Manche, MD

650 725 5765cornea@stanford.edu

Theresa Enriquez, HS

650 498 7020tenriquez@stanfordhealthcare.org

Locations

Byers Eye Institute at Stanford University School of Medicine

Recruiting

Palo Alto, California, United States, 94303

Contacts

Edward Manche, MD

650-498-7020

Principal Investigator:

Edward Manche, MD

More Information

Sponsor

Stanford University

Last update posted

Jan 22, 2026

Last verified

Jan, 2026

Keywords

  • Ray tracing-guided LASIK
  • Wavefront-guided LASIK

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Stanford University on 2026-01-22.