Recruiting

Grape Powder

Sponsor:

University of Connecticut

Code:

NCT07079982

Conditions

Healthy Aging

Inflammation

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Interventions

Freeze-dried whole grape powder

Control grape-free powder

Study Details

Brief summary:

The purpose of this study is to investigate the effects of consuming grape powder on immune profiles in healthy middle- and older-aged individuals. Specifically, the investigators are interested in evaluating the potential effects of grapes in influencing markers of immune function, inflammation, and metabolism that are known to change with aging. Grapes contain several nutrients and antioxidant polyphenols such as resveratrol, quercetin, vitamin K and fiber, which are known to promote heart and immune health. However, the effects of grapes on altering immune profiles within the context of aging is not well understood. Therefore, this study will explore how daily grape consumption impacts certain markers of immunity in healthy middle- and older-aged adults.

The main study procedures include consumption of a freeze-dried grape powder and control powder (which tastes the same but has none of the grape compounds that are being studied) mixed with water as a beverage on a daily basis for 4 weeks each. The investigators will additionally ask that participants avoid eating grapes and certain other antioxidant/grape-related foods and beverages throughout the 13-week study. Participants will additionally be asked to complete surveys about their diet, physical activity, and medical history, as well as provide blood samples and body weight measures throughout the course of the study. Participation in the study is expected to last about 6.25 hours over the course of 13 weeks and will include 7 visits.

Conditions

Healthy Aging

Inflammation

Study ID

NCT07079982

Start date

Jul 25, 2025

Status verified date

Jul, 2026

Completion date

Sep, 2027

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 50-75 years old (at time of screening)
  • Body mass index (BMI) 18.5 to < 30 kg/m2
  • Willing to consume grape and control powder during study periods, and refrain from eating grapes and certain other polyphenol-rich foods and beverages during the study
  • Do not fit any exclusion criteria

Exclusion Criteria:

  • <50 years old and >75 years old
  • BMI <18.5 and ≥ 30 kg/m2 or body weight < 110 pounds
  • Experienced >10% weight change in the past 4 weeks
  • Elevated fasting glucose levels (fasting glucose higher than 126 mg/dL) and triglycerides greater than 500 mg/dL
  • Self-reported and/or physician-diagnosed history of diabetes mellitus, coronary heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation
  • Allergy to grapes or any ingredients in the grape or control powders
  • Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedance
  • Currently taking lipid-lowering medications (e.g., statins, fibrates), glucose-regulating medications, anti-inflammatory medications (e.g., non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin), long-term antibiotics in the last 3 months, active use of probiotics during the intervention
  • Active smoker

Study Design

Enrollment

28 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Freeze-dried whole grape powder

placebo comparator: Control grape-free powder

Interventions

Freeze-dried whole grape powder

Studying the effects of freeze-dried whole grape powder on immune profiles in healthy aging adults

Control grape-free powder

Studying effects of a control grape-free powder on immune profiles in healthy aging

Primary outcome measure

  • Concentration of lipopolysaccharide (LPS)-induced interleukin-1 beta (IL-1beta) secreted from subject-derived primary immune cells ex vivo [ Time Frame: 4 weeks ]

Central Contacts and Locations

Central contacts

Catherine J Andersen, PhD, RDN

860-486-1704catherine.andersen@uconn.edu

Locations

Department of Nutritional Sciences

Recruiting

Storrs, Connecticut, United States, 06269

Contacts

Catherine J Andersen, PhD, RDN

860-486-1704catherine.andersen@uconn.edu

More Information

Sponsor

University of Connecticut

Last update posted

Aug 12, 2026

Last verified

Jul, 2026

Keywords

  • Grapes
  • Healthy aging
  • Inflammation
  • Immune profiles

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Connecticut on 2026-08-12.