Recruiting

CS Reducer

Sponsor:

Mayo Clinic

Code:

NCT07093528

Conditions

Heart Failure With Preserved Ejection Fraction

Coronary Microvascular Dysfunction

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Cardiovascular Magnetic Resonance (CMR)

Study Details

Brief summary:

To evaluate the effect of CS reducer implantation in patients with HFPEF and CMD on myocardial ischemia, measured by stress myocardial perfusion using cardiovascular magnetic resonance (CMR)

Conditions

Heart Failure With Preserved Ejection Fraction

Coronary Microvascular Dysfunction

Study ID

NCT07093528

Start date

Oct 16, 2025

Status verified date

Jan, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Aug, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥18
  • Enrollment in main CS-reducer HFPEF study IRB# 25-002292

Exclusion Criteria:

  • Metal implants that are not suitable for MRI
  • Inability or unwillingness of individual to give written informed consent.

Study Design

Enrollment

25 participants

Anticipated

Interventions and Outcome Measures

Arms

Heart Failure with a Preserved Ejection Fraction (HFpEF)

Subjects with diagnosed Heart failure with a preserved ejection fraction (HFpEF), non-obstructive Coronary Artery Disease (CAD), and have documented CMD.

Interventions

Cardiovascular Magnetic Resonance (CMR)

Patients will consent to undergo a 50-minute non-invasive stress perfusion CMR.

Primary outcome measure

  • Change in endocardial:epicardial perfusion ratio [ Time Frame: Baseline, 6 Months ]

Central Contacts and Locations

Central contacts

Diana Albers

507-255-6884albers.diana2@mayo.edu

Locations

Mayo Clinic

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Diana Albers

507-255-6884albers.diana2@mayo.edu

Principal Investigator:

Claire Raphael, M.B.B.S., Ph.D.

More Information

Sponsor

Mayo Clinic

Last update posted

Feb 27, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-02-27.