Recruiting

Observational Study

Sponsor:

University of Michigan

Code:

NCT07094061

Conditions

Substance Use

Healthy

Eligibility Criteria

Sex: All

Age: 18 - 22

Healthy Volunteers: Accepted

Interventions

fMRI

Questionnaires and surveys

Behavioral tasks and eye tracking

Study Details

Brief summary:

This study seeks to understand individual differences in personality, brain function, and behavior.

Study hypothesis:

\- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.

Conditions

Substance Use

Healthy

Study ID

NCT07094061

Start date

Oct 3, 2025

Status verified date

Jun, 2026

Completion date

Aug, 2028

Anticipated

Primary completion date

Aug, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 22

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18-22 years old at baseline
  • Right-handed
  • Medically/physically able to give informed consent
  • English-speaking
  • Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)

Exclusion Criteria:

  • Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
  • History of psychosis in self or first-degree relative
  • Current treatment for substance use disorder
  • Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
  • Intelligence quotient (IQ) < 70
  • Lifetime history of head trauma with loss of consciousness > 5 minutes
  • Reliance on glasses to be able to read small text at a distance of approximately 30 inches
  • Colorblindness
  • MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol

Study Design

Enrollment

294 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Assessment group

Interventions

fMRI

Participants will have an MRI to scan participants brains and will wear skin conductance electrodes on the hand and fill out questionnaires. Scanning will take approximately 90 minutes. While lying in the scanner, participants will be asked to perform some tasks. The tasks will be presented to participants visually on a screen in the scanner and eye movements will also be tracked during some of these tasks. Participants will respond to stimuli with button presses that are recorded by computer.

Questionnaires and surveys

Participants will have multiple visits during this study and fill out various surveys at these visits.

Behavioral tasks and eye tracking

Participants will perform behavioral tasks while having eye-tracking hardware monitor participants eye movements. A video camera will be used to record eye movements during the behavioral tasks.

Primary outcome measure

  • Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Paul Holdefer, MPH

734-998-9239holdefer@umich.edu

Locations

Rachel Upjohn Building

Recruiting

Ann Arbor, Michigan, United States, 48109

Contacts

Loree Brennan O'Jack, CPA, MHSA

734-232-0227loree@med.umich.edu

Principal Investigator:

Lora M Cope, PhD

More Information

Sponsor

University of Michigan

Last update posted

Jun 10, 2026

Last verified

Jun, 2026

Keywords

  • Functional magnetic resonance imaging (fMRI)
  • Questionnaires
  • Interviews
  • Behavioral tasks

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Michigan on 2026-06-10.