Recruiting

Plant-Based Nutrition

Sponsor:

Physicians Committee for Responsible Medicine

Code:

NCT07095543

Conditions

Type 2 Diabetes

Overweight and Obese Adults

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Low-fat, vegan diet

Study Details

Brief summary:

This is an interventional study that will evaluate the feasibility, implementation, and efficacy of an online, 12-week, plant-based, nutrition education program in a community setting. Participants will meet with a physician and a registered dietitian once a week to learn about a plant-based diet and receive support and practical help in making the dietary changes. Body composition, blood sugar control, cholesterol levels, and food costs will be measured at the start and end of the study.

Conditions

Type 2 Diabetes

Overweight and Obese Adults

Study ID

NCT07095543

Start date

Jan 2, 2026

Status verified date

Sep, 2026

Completion date

Oct 30, 2028

Anticipated

Primary completion date

Oct 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • U.S. men and women meeting the age of majority, defined as follows:

Age 19 or older in Nebraska and Alabama. Age 21 or older in Puerto Rico. Age 18 or older in all other states.

  • Able and willing to travel to Washington DC for a dual-energy х-rау absorptiometry (DXA) scans before and after the program.
  • Able and willing to complete laboratory assessments at a local LabCorp facility before and after the program.
  • Able and willing to participate in all components of the study.
  • BMI of 25 or more (23 or more in persons of Asian origin).
  • Access to the internet.
  • English fluency.

Exclusion Criteria:

  • Use of recreational drugs in the past 6 months.
  • Pregnancy or intention to become pregnant during the study period, as verified by self-report.
  • Unstable medical or psychiatric illness.
  • Inability to maintain medication regimen as prescribed by personal healthcare provider.
  • Current or expected use of any weight loss medication during the study period, including but not limited to, glucagon-like peptide-1 (GLP-1) receptor agonists and combination GLP-1 receptor/glucose-dependent insulinotropic polypeptide (GIP) agonists.
  • Use of any weight loss medication within the 12 months preceding the study period, including but not limited to, glucagon-like peptide-1 (GLP-1) receptor agonists and combination GLP-1 receptor/glucose-dependent insulinotropic polypeptide (GIP) agonists.
  • Body weight greater than 182 kg.
  • Current diagnosis of eating disorder.
  • Intention to follow another weight loss method during the study period.

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Low-fat, vegan diet

All participants will be asked to follow a low-fat vegan diet. There are no other study arms or control group.

Interventions

Low-fat, vegan diet

All participants will be asked to follow a low-fat vegan diet for the duration of the study. Participants will attend weekly classes where they we receive education and support.

Primary outcome measure

  • The feasibility of an online plant-based weight loss program in the community setting. [ Time Frame: From baseline to the end of the intervention at 12 weeks. ]

Central Contacts and Locations

Central contacts

Vanita Rahman, MD, DipACLM

202-527-7500vrahman@pcrm.org

Shannon Menhardt, MS, RD

202-527-7500smenhardt@pcrm.org

Locations

Physicians Committee for Responsible Medicine

Recruiting

Washington D.C., District of Columbia, United States, 20016

Contacts

Vanita Rahman, MD

202-527-7500vrahman@pcrm.org

More Information

Sponsor

Physicians Committee for Responsible Medicine

Last update posted

Sep 17, 2026

Last verified

Sep, 2026

Keywords

  • Plant-based diet
  • Vegan diet
  • type 2 diabetes
  • Weight loss
  • Overweight
  • Obesity
  • Cholesterol

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-18. This information was provided to ClinicalTrials.gov by Physicians Committee for Responsible Medicine on 2026-09-17.