Recruiting

Nd-YAG Laser

Sponsor:

Medical University of South Carolina

Code:

NCT07095556

Conditions

Wound Healing and Prevention

Oral Inflammation

Photobiomodulation

Post-operative Pain Management

Tooth Extraction Site Healing

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Low-level laser therapy

Study Details

Brief summary:

The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation. Investigators plan to assess the impact of laser treatment on wound healing by measuring salivary biomarkers, gingival wound size and surveying for the use of pain reduction and patient satisfaction. The intervention group will receive extraction and alveolar ridge preservation with Nd-YAG laser photobiostimulation on days 1, 3, and 7 following extraction and socket preservation, while the control group will receive the standard of care extraction and alveolar ridge preservation without the laser

Conditions

Wound Healing and Prevention

Oral Inflammation

Photobiomodulation

Post-operative Pain Management

Tooth Extraction Site Healing

Study ID

NCT07095556

Start date

Nov 5, 2025

Status verified date

Nov, 2025

Completion date

Apr 30, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Participants who are ≥ 18 years old,
  • Patients who are scheduled for the treatment of tooth extraction and alveolar ridge preservation (ARP)
  • No contraindications for tooth extraction and alveolar ridge preservation based on electronic health records.
  • Participants who can express the level of pain
  • Participants who self-report "not pregnant"

Exclusion Criteria:

  • Untreated periodontal disease
  • Acute infection of the teeth
  • Use of antibiotics within the last three months.
  • Pregnant or lactating women
  • Use of bisphosphonates based on EHR
  • Alveolar bone defects occurred or were detected during tooth extraction

Study Design

Enrollment

39 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

no intervention: Control

Sham laser will be applied instead of the low-level laser.

experimental: Intervention

Low-level lase therapy will be applied at tooth extraction sites.

Interventions

Low-level laser therapy

The low-level laser applications will be made on the same day as the standard of care treatment (day 1), and then day 3, and day 7 by a study team member who is trained in the use of the laser device.

The laser photobiostimulation will be applied using LightWalker® laser (FOTONA), with following settings, Nd:YAG laser 1064 nm, MSP modality (pulse duration), 0.5 W (power), 10 Hz (frequency), 1 min/ 1 cm2 spot using Genova handpiece from buccal, lingual, and occlusal aspects. The Genova handpiece will be placed 1 cm away from gingival tissue.

Participants and operators will wear glasses to protect their eyes from laser beam in all sessions.

Primary outcome measure

  • Inflammatory markers in saliva [ Time Frame: From day of tooth extraction through day 7 ]
  • Wound size dimensional changes [ Time Frame: From the day of tooth extraction to day 42 ]
  • Post-operative pain [ Time Frame: From post-operative day 3 to day 14 ]

Central Contacts and Locations

Central contacts

Pinar Emecen-Huja

(843) 792-5688emecenh@musc.edu

Locations

MUSC College of Dental Medicine, Graduate Periodontics Clinic

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Joe Gambacorta, DDS

843-876-7645gambacor@musc.edu

Ben (Hua-Hong) Chien, DDS

chienh@musc.edu

More Information

Sponsor

Medical University of South Carolina

Last update posted

Nov 12, 2025

Last verified

Nov, 2025

Keywords

  • Inflammation
  • Periodontal Disease
  • low-level laser therapy
  • gingival healing
  • Post-operative pain

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Medical University of South Carolina on 2025-11-12.