Recruiting

Protective Ventilation

Sponsor:

Laval University

Code:

NCT07099963

Conditions

Thoracic

Surgery

Mechanical Ventilation

Hypercapnia

Acidosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

one lung ventilation

Study Details

Brief summary:

One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml/kg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.

Conditions

Thoracic

Surgery

Mechanical Ventilation

Hypercapnia

Acidosis

Study ID

NCT07099963

Start date

Aug 1, 2025

Status verified date

Aug, 2025

Completion date

Jun, 2026

Anticipated

Primary completion date

Dec, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults (≥ 18 years old)
  • Patients intubated and undergoing one-lung ventilation during thoracic surgery
  • Volume-controlled ventilation mode used intraoperatively

Exclusion Criteria:

  • Arterial blood gas data unavailable during one-lung ventilation
  • Missing demographic data (sex, height, actual weight)

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Arms

Thoracic surgery

Patient managed with one lung ventilation

Interventions

one lung ventilation

Arterial blood gases during one lung ventilation

Primary outcome measure

  • Respiratory acidosis [ Time Frame: 20 minutes after initiation of one lung ventilation after lung isolation ]

Central Contacts and Locations

Central contacts

Locations

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

Recruiting

Québec, Quebec, Canada, G1V4G5

Contacts

More Information

Sponsor

Laval University

Last update posted

Aug 6, 2025

Last verified

Aug, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Laval University on 2025-08-06.