Recruiting

Psychosocial Interventions

Sponsor:

University of Pittsburgh

Code:

NCT07107165

Conditions

Stem Cell Transplant

Hematopoetic Stem Cell Transplant

Hematopoetic Stem Cell Transplantation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Dyadic Problem Solving Training

Supportive Care

Study Details

Brief summary:

Adherence to the medical regimen after stem cell transplant is challenging for both patients and their family caregivers. The investigators propose a randomized clinical trial testing two brief psychosocial interventions to determine if either improves patient and family caregiver psychosocial and health-related outcomes.

Conditions

Stem Cell Transplant

Hematopoetic Stem Cell Transplant

Hematopoetic Stem Cell Transplantation

Study ID

NCT07107165

Start date

Jul 1, 2025

Status verified date

Mar, 2026

Completion date

Jul, 2027

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient undergoing a stem cell transplant at the University of Pittsburgh Hillman Cancer Center
  • 18 years or older
  • having a family caregiver age 18 years or older also willing to participate in the study
  • willing to accept randomization

Exclusion Criteria:

  • Prior history of stem cell transplant
  • Non-English speaking

Study Design

Enrollment

208 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Dyadic Problem Solving Training (DPST)

DPST will teach problem solving skills to both the patient and family caregiver as they manage the medical regimen.

active comparator: Supportive Care

Supportive Care will provide support to both the patient and family caregiver as they manage the medical regimen.

Interventions

Dyadic Problem Solving Training

DPST consists of teaching the patient and family caregiver problem-solving skills that they can apply to help them manage the medical regimen after stem cell transplant.

Supportive Care

Supportive Care consists of providing support to the patient and family caregiver as they manage the medical regimen after stem cell transplant

Primary outcome measure

  • Health Habits Assessment - modified for stem cell transplant [ Time Frame: 1-, 5-, 12- and 24-weeks post-intervention ]
  • Perceived task efficacy [ Time Frame: 1-, 5-, 12- and 24-weeks post intervention ]

Central Contacts and Locations

Central contacts

Donna Posluszny, PhD

412-623-5966poslusznydm@upmc.edu

Locations

University of Pittsburgh Medical Center Hillman Cancer Center

Recruiting

Pittsburgh, Pennsylvania, United States, 15232

Contacts

Donna Posluszny, PhD

412-623-5966poslusznydm@upmc.edu

Principal Investigator:

Donna Posluszny, PhD

More Information

Sponsor

University of Pittsburgh

Last update posted

Apr 1, 2026

Last verified

Mar, 2026

Keywords

  • stem cell transplant
  • hematopoietic stem cell transplant

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Pittsburgh on 2026-04-01.