Recruiting

CLABSI vs. RoutineMachine Learning Prediction of Possible Central Line Associated Blood Stream Infections and Rate of Reduction

Sponsor:

Swedish Medical Center

Code:

NCT07108660

Conditions

Central Line Associated Blood Stream Infections (CLABSI)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Infection Preventionist Led Best Practices Reminders

Study Details

Brief summary:

Prospective, multi-center, cluster-randomized trial of a hospital Infection Preventionist (IP)-led quality improvement study to provide clinical teams with just-in-time clinical education and reinforcement of existing best practices recommendations based on the output of a possible Central Line Associated Blood Stream Infection (CLABSI) Machine Learning (ML) prediction model.

The objective is to determine whether providing this model to Infection Preventionists will decrease the CLABSI rates versus routine clinical practice.

Conditions

Central Line Associated Blood Stream Infections (CLABSI)

Study ID

NCT07108660

Start date

Jul 1, 2025

Status verified date

Aug, 2025

Completion date

Dec, 2027

Anticipated

Primary completion date

Nov, 2025

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

The top twenty Providence St. Joseph Health Hospitals by CLABSI burden.

Exclusion Criteria:

Less than 18 years of age

Study Design

Enrollment

17800 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: Hospitals receiving "EARLY" access to the prediction model.

During the study period, the "EARLY" hospitals receive access to the Possible CLABSI ML model.

no intervention: Hospitals receiving "LATE" access to the prediction model.

During the comparison period, the "LATE" hospitals do not receive access to the Possible CLABSI ML model.

Interventions

Infection Preventionist Led Best Practices Reminders

Infection preventionists at each study hospital review a dashboard on a daily basis that contains predictions for the infection preventionist's hospital. If a patient is predicted to have a possible CLABSI by the ML model, the infection preventionist reviews the case and recommends next steps to the care team based on Providence's CLABSI prevention best-practices bundle, which include reviewing the line for necessity and recommending alternate IV access when appropriate. If line-removal isn't possible, the infection preventionist collaborates with the direct care team to ensure that the line maintenance best practices are observed, including maintaining a clean, dry and intact dressing and using daily chlorhexidine baths.

Primary outcome measure

CLABSI Rate [ Time Frame: Day 1 of Hospitalization thru Discharge ]

Central Contacts and Locations

Central contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Evan Sylvester, MPH

425-681-6961 evan.sylvester@providence.org

Locations

Providence Alaska Medical Center

Recruiting

Anchorage, Alaska, United States, 99508

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

St. Mary Medical Center

Recruiting

Apple Valley, California, United States, 92307

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Providence Saint Joseph Medical Center

Recruiting

Burbank, California, United States, 91505

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

St. Jude Medical Center

Recruiting

Fullerton, California, United States, 92835

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Providence Holy Cross Medical Center

Recruiting

Mission Hills, California, United States, 91345

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Mission Hospital

Recruiting

Mission Viejo, California, United States, 92691

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Queen of the Valley Medical Center

Recruiting

Napa, California, United States, 94558

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

St. Joseph Hospital

Recruiting

Orange, California, United States, 92868

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Santa Rosa Memorial Hospital

Recruiting

Santa Rosa, California, United States, 95405

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Providence Cedars-Sinai Tarzana Medical Center

Recruiting

Tarzana, California, United States, 91356

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Providence St. Vincent Medical Center

Recruiting

Portland, Oregon, United States, 97225

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Covenant Medical Center

Recruiting

Lubbock, Texas, United States, 79416

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Swedish Medical Center Edmonds

Recruiting

Edmonds, Washington, United States, 98026

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Providence Regional Medical Center Everett

Recruiting

Everett, Washington, United States, 98201

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Providence St. Peter Hospital

Recruiting

Olympia, Washington, United States, 98506

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Kadlec Regional Medical Center

Recruiting

Richland, Washington, United States, 99352

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Swedish Medical Center Cherry Hill

Recruiting

Seattle, Washington, United States, 98122

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Swedish Medical Center First Hill

Recruiting

Seattle, Washington, United States, 98122

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

Providence Sacred Heart Medical Center

Recruiting

Spokane, Washington, United States, 99204

Contacts

Chris Dale, MD, MPH

425-747-5822 christopher.dale@swedish.org

More Information

Sponsor

Swedish Medical Center

Last update posted

Aug 15, 2025

Last verified

Aug, 2025

Keywords

Inpatient
CLABSI
Central Line Associates Blood Stream Infections
Infection Prevention
Artificial Intelligence
Machine Learning
Healthcare Associated Infection
HAI

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Swedish Medical Center on 2025-08-15.