Recruiting

HEPA Air Cleaners

Sponsor:

Columbia University

Code:

NCT07116460

Conditions

Asthma Attack

Lung Function

Airway Inflammation

Eligibility Criteria

Sex: All

Age: 7 - 18

Healthy Volunteers: Not accepted

Interventions

Austin Air Cleaner

Study Details

Brief summary:

This project will investigate the effectiveness of HEPA air cleaners in reducing indoor air pollution and improving asthma morbidity in children living in East Harlem, New York City (NYC). The study will be conducted over a 2-year period.

Columbia University and Little Sisters of the Assumption Family Health Service (LSAFHS) will conduct an intervention study to evaluate the efficacy of using a cost-effective high-capacity high efficiency particulate air (HEPA) filter air cleaner to reduce airborne particulate matter (PM) in the homes of children with asthma and to reduce their asthma morbidity. The study will take place in East Harlem, a low-income neighborhood with high asthma prevalence. It will build on findings from prior Housing and Urban Development Lead and Healthy Homes Technical Studies (HUD LHHTS)-funded research, the experience of LSAFHS installing air cleaners in the homes of asthmatic children, and recent findings demonstrating the effectiveness of home air cleaners in reducing asthma morbidity. The investigators hypothesize that the cost-effective single air cleaner will substantially reduce PM exposure in the homes of asthmatic children and reduce airway inflammation and asthma morbidity. This study will use cutting-edge air sampling technology to continuously quantify and characterize indoor air pollutants in the home for one year, verify and incentivize compliance, and conduct repeated exhaled nitric oxide and pulmonary function tests before and throughout the year after the intervention. This cost-effective intervention can be easily and quickly implemented in homes in low-income, urban communities and easily transferred between homes if families move.

Conditions

Asthma Attack

Lung Function

Airway Inflammation

Study ID

NCT07116460

Start date

Jan 30, 2026

Status verified date

May, 2026

Completion date

Apr, 2028

Anticipated

Primary completion date

Apr, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 7 - 18

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 7-18 years
  • Asthma symptoms in the past 4 weeks
  • Resident in lower-income housing in NYC Northern Manhattan and South Bronx

Exclusion Criteria:

  • Inability to successfully perform spirometry maneuver or FeNO test
  • Family planning to move in the next year

Study Design

Enrollment

55 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Air Cleaner Intervention

Participants in this single arm of the study will be enrolled for a one-year trial of a HEPA air cleaner. Subjects will serve as their own controls.

Interventions

Austin Air Cleaner

The Austin Air Purifier consists of 4 stages, a large particle pre-filter, medium pre-filter, a medical grade HEPA filter and a high efficiency gas arrestance carbon cloth to reduce air pollution in homes.

Primary outcome measure

  • Fractional Exhaled Nitric Oxide (FeNO) [ Time Frame: 1 week before, immediately before, two weeks after, and one year after the air cleaner is turned on. ]
  • Forced Expiratory Volume in 1 Second/ Forced Vital Capacity (FEV1/FVC) Ratio [ Time Frame: 1 week before, immediately before, two weeks after, then once a month (up to 1 year) after the air cleaner is turned on. ]
  • Number of Attacks of Wheezing [ Time Frame: Once per month for up to 12 months after the air cleaner is turned on ]
  • Number of Emergency Department (ED) Visits [ Time Frame: 12 months after the air cleaner is turned on ]

Central Contacts and Locations

Central contacts

Locations

Columbia University Irving Medical Center

Recruiting

New York, New York, United States, 10032

More Information

Sponsor

Columbia University

Last update posted

Jun 2, 2026

Last verified

May, 2026

Keywords

  • asthma
  • air cleaner
  • particulate matter
  • pm2.5
  • lung function
  • airway inflammation
  • children

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Columbia University on 2026-06-02.