Recruiting

Cervical Cancer Biology

Sponsor:

UCLA

Code:

NCT07121543

Conditions

Cervical Cancer

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Brachytherapy

Study Details

Brief summary:

The goal of this observational study is to learn more about the biology of cervical cancer in women who receive radiation therapy for this condition. The main question it aims to answer is:

Does radiation therapy alter the expression of tissue factor and other molecules in cervical cancer over time?

Participants already scheduled for radiation therapy for cervical cancer as part of their regular medical care will provide blood and biopsies of cervical cancer or of the upper portion of the vagina before, during, and on the last day of radiation therapy.

Conditions

Cervical Cancer

Study ID

NCT07121543

Start date

Aug 4, 2025

Status verified date

Aug, 2025

Completion date

Aug, 2027

Anticipated

Primary completion date

Aug, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 years or older
  • Pathological diagnosis of cervical cancer
  • Scheduled to receive brachytherapy for cervical cancer

Exclusion Criteria:

  • Pregnancy or lactation
  • Inability to provide a tissue sample

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Arms

Cervical cancer biopsy

Using tumor biopsies collected before, during, and after radiotherapy, the investigators will:

1. Evaluate if irradiation alters tissue factor expression in tumors.
2. Determine the temporal changes of biomarkers in the irradiated tumor immune microenvironment.

Vaginal apex biopsy

Using vaginal tissue biopsies collected before, during, and after radiotherapy, the investigators will:

1. Evaluate if irradiation alters biomarkers of fibrosis in the vaginal tissue.
2. Determine the temporal changes of inflammatory biomarkers that increases the stenosis molecular cascade in the irradiated tumor immune microenvironment.

Interventions

Brachytherapy

Brachytherapy is a cancer treatment where radioactive sources are placed inside or near the tumor.

Primary outcome measure

  • Tissue factor expression in tumors [ Time Frame: 8 weeks ]

Central Contacts and Locations

Central contacts

Jyoti Mayadev, MD

858-822-5354CancerCTO@health.ucsd.edu

Erika Peterson

858-822-5354CancerCTO@health.ucsd.edu

Locations

University of California San Diego

Recruiting

La Jolla, California, United States, 92093

Contacts

Project Manager

858-822-5354CancerCTO@health.ucsd.edu

More Information

Sponsor

University of California, San Diego

Last update posted

Aug 13, 2025

Last verified

Aug, 2025

Keywords

  • Radiotherapy
  • Cervical cancer
  • Translational research
  • Biomarkers

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Diego on 2025-08-13.