Recruiting

Mangos

Sponsor:

UCLA

Code:

NCT07125001

Conditions

Cardiometabolic Health Indicators

Vascular Function in Healthy Volunteers

Inflammation

Eligibility Criteria

Sex: All

Age: 12 - 19

Healthy Volunteers: Accepted

Interventions

Ataulfo mango

Study Details

Brief summary:

Mangos contain a number of nutrients that may improve gut and metabolic health. The purpose of this research is to see how eating mangos every day for 4 weeks instead of snacks high in calories and low in nutrients such as cookies, crackers, chips, and candy can impact adolescent health.

Conditions

Cardiometabolic Health Indicators

Vascular Function in Healthy Volunteers

Inflammation

Study ID

NCT07125001

Start date

Oct 1, 2025

Status verified date

Jan, 2026

Completion date

Mar 31, 2028

Anticipated

Primary completion date

Mar 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 12 - 19

Healthy Volunteers: Accepted

Inclusion Criteria:

  • \- Male or Female 12-19 years old
  • BMI ≥ 85th percentile (https://www.bcm.edu/bodycomplab/BMIapp/BMI-calculator-kids.html)
  • Self-reported Hispanic/Latino
  • Subject is willing and able to comply with the study protocols
  • Subject is willing to consume the test products
  • Female-specific criteria: if menstruating, eumenorrheic (regular monthly menstrual cycles of 25-30-days in length)
  • Access to a smartphone or tablet at least 1x / day and willing to take pictures associated with the products to be consumed in the study

Exclusion Criteria:

  • \- Reported food allergies.
  • Currently taking prescription drugs, with the exception of asthma inhalers, which are allowed
  • BMI <85th percentile (https://www.bcm.edu/bodycomplab/BMIapp/BMI-calculator-kids.html)
  • Current participation in a moderate or high-intensity daily exercise routine
  • Self-reported disease, serious illness, or who are currently under acute medical care.
  • Currently taking prescription drugs.
  • Any supplement use, including multi-vitamin/ mineral, herbal, plant or botanical, fish oil, and oil supplements, and not willing to discontinue before starting the study.
  • Vegetarian or vegan diet
  • Self-reported malabsorption or gastrointestinal issues
  • Fruit and vegetable intake exceeding daily recommendations of 5 servings
  • Smoking (vaping, conventional nicotine-containing products or marijuana)
  • Current enrollee in a clinical research study

Study Design

Enrollment

25 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Mango arm

Ataulfo Mango intake

no intervention: No mango intake

4 weeks of no mango intake

Interventions

Ataulfo mango

4 weeks of Ataulfo mango intake

Primary outcome measure

  • Microvascular Function [ Time Frame: 4 weeks ]

Central Contacts and Locations

Central contacts

Roberta R Holt, PhD

15304005952rrholt@ucdavis.edu

Genesis G Guerra Gaitan, MS

gguerragaitan@ucdavis.edu

Locations

Academic Surge; Ragle Human Nutrition Research Center

Recruiting

Davis, California, United States, 95616

Contacts

Roberta R Associate Researcher, PhD

530-400-5952

California

530-400-5952

More Information

Sponsor

University of California, Davis

Last update posted

Feb 3, 2026

Last verified

Jan, 2026

Keywords

  • mango
  • cardiometabolic
  • adolescents
  • microbiome

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, Davis on 2026-02-03.