Recruiting

Brain Stimulation

Sponsor:

Arcadia University

Code:

NCT07128602

Conditions

Anterior Cruciate Ligament Reconstruction Rehabilitation

Quadriceps Muscle Function

Eligibility Criteria

Sex: Female

Age: 18 - 35

Healthy Volunteers: Not accepted

Interventions

active transcranial direct current stimulation (tDCS)

sham transcranial direct current stimulation (tDCS)

Study Details

Brief summary:

After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles. Our research tests a new approach to improve recovery by using low-level brain stimulation to boost these signals. The investigators will study 42 women, aged 18-35, who had ACL surgery. They'll be split into two groups: one receiving real brain stimulation and another getting a placebo, both during thigh-strengthening exercises. Over six sessions, the investigators measure thigh muscle strength, speed, and steadiness, plus two brain signal measures, using special equipment. The investigators will also check if stronger brain signals lead to better muscle performance, especially in women. Our goal is to show that this new method strengthens thigh muscles better than standard rehab, helping women recover better after surgery. If successful, this could improve physical therapy for women recovering from ACL surgery, making daily activities and return to sport easier.

Conditions

Anterior Cruciate Ligament Reconstruction Rehabilitation

Quadriceps Muscle Function

Study ID

NCT07128602

Start date

Jun 6, 2025

Status verified date

May, 2026

Completion date

Mar 1, 2028

Anticipated

Primary completion date

Jan 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 35

Healthy Volunteers: Not accepted

Inclusion Criteria:

\- females 2-6 months after ACL reconstruction

Exclusion Criteria:

  • multiple ligament reconstruction
  • osteochondral procedures
  • any previous lower extremity surgery
  • previous ACL injury
  • Metal or implants in the head or neck
  • history of neurological disease
  • seizures
  • severe migraines
  • concussion within the last 6 months

Study Design

Enrollment

42 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Active tDCS

This group will receive 20 minutes of active anodal tDCS

sham comparator: Sham tDCS

This group will receive sham anodal tDCS. The tDCS unit will be active for the first 30 seconds and the last 30 seconds only.

Interventions

active transcranial direct current stimulation (tDCS)

20 minutes of anodal tDCS over the primary motor cortex contralateral to the participants surgical limb during a quadriceps torque matching task

sham transcranial direct current stimulation (tDCS)

Participants receive sham tDCS in which the device only delivers current during the first and last 30 seconds while participants perform a quadriceps torque matching task

Primary outcome measure

  • Peak quadriceps muscle torque [ Time Frame: Pre and post intervention ]
  • Corticospinal excitability (Slope) [ Time Frame: Pre and post intervention ]

Central Contacts and Locations

Central contacts

Locations

Ryan Zarzycki

Recruiting

Glenside, Pennsylvania, United States, 19038

Contacts

More Information

Sponsor

Arcadia University

Last update posted

May 7, 2026

Last verified

May, 2026

Keywords

  • acl
  • acl reconstruction
  • corticospinal excitability
  • non-invasive brain stimulation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Arcadia University on 2026-05-07.