Recruiting

Observational Study

Sponsor:

University of Minnesota

Code:

NCT07134426

Conditions

Former Smoker

Non-Smoker

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Interventions

D10-phenanthrene

Study Details

Brief summary:

Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former smokers through more harmful pathways than never-smokers. If former smokers break down chemicals that enter their lungs through more harmful pathways this might be putting them at higher risk for developing lung cancer even though they quit smoking. This information may help find better ways to prevent or treat cancer in the future.

This study is under an IND, but the drug is not being studied; instead, it is being used as a marker for drug metabolism.

Conditions

Former Smoker

Non-Smoker

Study ID

NCT07134426

Start date

Sep 1, 2026

Status verified date

Sep, 2026

Completion date

Jun 30, 2028

Anticipated

Primary completion date

Sep 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • > 21 years of age
  • In good physical \& mental health
  • In stable physical \& mental health
  • Have tried vaping
  • Former daily cigarette smokers who quit 1-20 year ago
  • Non-smokers who have not used tobacco or nicotine products

Exclusion Criteria:

  • Has any respiratory disease (ex - asthma, COPD, etc...)
  • Has/had high blood pressure
  • Has/had liver disease
  • Has/had cancer
  • Has experience negative effects when vaped previously
  • Pregnant or nursing

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: D10-phenanthrene

All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons \[PAHs\].

Interventions

D10-phenanthrene

All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons \[PAHs\].

Primary outcome measure

  • Urinary Ratio of D10PheT/D9PhOH [ Time Frame: 24 hours after vaping phenanthrene ]
  • TNE [ Time Frame: Baseline measure ]

Central Contacts and Locations

Central contacts

Aleksandra Alcheva

612-422-8902alche003@umn.edu

Locations

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Aleksandra Alcheva

612-422-8902alche003@umn.edu

More Information

Sponsor

University of Minnesota

Last update posted

Sep 3, 2026

Last verified

Sep, 2026

Keywords

  • Smoking
  • Tobacco
  • Vaping
  • Former Smoker
  • Non-Smoker

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-09-03.