Recruiting

Breath-Holding Techniques

Sponsor:

UCLA

Code:

NCT07135401

Conditions

MRI

MRI Image Enhancement

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Breath-hold conditions

Study Details

Brief summary:

The goal of this interventional study (clinical trial) is to learn if different breath-holding techniques, with and without extra oxygen, can improve the quality of abdominal Magnetic Resonance Imaging (MRI) images in healthy adults, ages 18-75.

The main questions it aims to answer are:

  • Does breath-holding at end-expiration improve image quality in abdominal MRI scans?
  • Does adding oxygen while breath-holding further reduce motion artifacts in abdominal MRI scans?

Researchers will compare breath-holding with and without oxygen to see if using oxygen improves image quality during MRI scans.

Participants will:

  • Be pre-screened for MRI safety and trained on breath-hold procedures
  • Have one non-contrast abdominal MRI scan at the University of California San Francisco (UCSF) China Basin Imaging Center
  • Use two different breath-holding techniques during the scan, with and without oxygen
  • Complete one study visit lasting about 45 minutes to 1 hour

Conditions

MRI

MRI Image Enhancement

Study ID

NCT07135401

Start date

Dec 1, 2025

Status verified date

Apr, 2026

Completion date

Aug 1, 2026

Anticipated

Primary completion date

Jun 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Subject must be within 18-75 years of age;
  • Subject must be able to hear and understand instructions without assistive devices;
  • Subject must provide written informed consent;
  • Subject has the necessary mental capacity to understand instructions, and is able to comply with protocol requirements;
  • Subject is able to remain still for duration of imaging procedure (approximately 30-45 minutes)

Exclusion Criteria:

  • Subjects with a weight greater than 499 lbs;
  • Subjects that have metallic/conductive or electrically/magnetically active implants without Magnetic Resonance (MR) Safe or Magnetic Resonance (MR) Conditional labeling, with the exception of dental devices/fillings, surgical clips, and surgical staples determined to be safe for MRI scanning by a physician investigator;
  • Subjects that have implants with MR Unsafe labeling;
  • Subjects that have implants labeled as MR Conditional by the manufacturer for which the allowable conditions are not expected to be achieved by the MR environment or scan protocol;
  • Subjects who have a contraindication to MRI per the screening policy of the participating site;
  • Subjects with any respiratory or cardiovascular condition that could compromise safe breath holding;
  • Subjects who are female and pregnant

Study Design

Enrollment

10 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Functional Residual Capacity/End-Expiration Without Oxygen

Participants will undergo abdominal MRI scans while performing breath-holding at end-expiration without oxygen supplementation. T2-weighted and MRCP sequences will be acquired during breath-hold trials.

experimental: Functional Residual Capacity/End-Expiration With Oxygen

Participants will undergo abdominal MRI scans while performing breath-holding at end-expiration with oxygen supplementation administered prior to. T2-weighted and MRCP sequences will be acquired during breath-hold trials.

Interventions

Breath-hold conditions

Functional Residual Capacity/End-Expiration (breath-hold technique) with/without oxygen to optimize MRI image quality.

Primary outcome measure

  • Liver MRI Image Quality (Motion Artifacts) [ Time Frame: During the single MRI session (approximately 1 hour) ]

Central Contacts and Locations

Central contacts

John P Roberts, MD

415-353-3677John.Roberts@ucsf.edu

Locations

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94143

Contacts

Holland Stacey Stacey

415-420-5100holland.stacey@ucsf.edu

More Information

Sponsor

University of California, San Francisco

Last update posted

Apr 13, 2026

Last verified

Apr, 2026

Keywords

  • abdominal MRI
  • breath-hold technique
  • functional residual capacity
  • image quality
  • non-contrast MRI
  • liver MRI
  • end-expiration
  • preoxygenation
  • oxygen supplementation
  • radiology
  • respiratory motion control
  • T2-weighted imaging
  • living liver donor
  • motion artifact
  • 3T MRI
  • UCSF
  • motion artifact reduction
  • hyperventilation
  • end-inspiration

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-04-13.