Recruiting

Vaccine & AntibodiesInduction of Cross-protective Antibodies for Serogroup 33 by Pneumococcal Conjugate Vaccines

Sponsor:

University of Alabama at Birmingham

Code:

NCT07135453

Conditions

Vaccine

Pneumococcal Disease

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Pneumococcal Vaccine

Study Details

Brief summary:

The goal of this study is to learn whether different types of vaccines to prevent bacterial infections are able to effectively create antibodies that defend against certain types of bacteria.

We will give two different types of vaccine and evaluate the effectiveness of antibodies produced by each vaccine in killing bacteria.

Conditions

Vaccine

Pneumococcal Disease

Study ID

NCT07135453

Start date

Jul 1, 2026

Status verified date

Jul, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Mar, 2027

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

Healthy adult

Exclusion Criteria:

No prior history of pneumococcal vaccination
No immunosuppressing medications or chronic diseases that affect immune function

Study Design

Enrollment

70 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: PCV20

Will receive PCV20

experimental: PCV21

Will receive PCV21

Interventions

Pneumococcal Vaccine

PCV

Primary outcome measure

Serogroup 33 antibodies [ Time Frame: 4 weeks post-vaccination ]
Antibody-mediated killing [ Time Frame: 4 weeks post-vaccination ]

Central Contacts and Locations

Central contacts

David LaFon, MD

2059343411 dlafon@uabmc.edu

Locations

University of Alabama at Birmingham

Recruiting

Birmingham, Alabama, United States, 35294

Contacts

LaFon, MD

2059343411 dlafon@uabmc.edu

Principal Investigator:

David C LaFon, MD

More Information

Sponsor

University of Alabama at Birmingham

Last update posted

Aug 21, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Alabama at Birmingham on 2026-08-21.