Sponsor:
Amgen
Code:
NCT07136012
Conditions
Cardiovascular Disease
Eligibility Criteria
Sex: All
Age: 50 - 70+
Healthy Volunteers: Not accepted
Interventions
Olpasiran
Placebo
Brief summary:
Conditions
Cardiovascular Disease
Study ID
NCT07136012
Start date
Aug 22, 2025
Status verified date
Aug, 2026
Completion date
Oct 20, 2031
Anticipated
Primary completion date
Oct 20, 2031
Anticipated
Eligibility Criteria
Sex: All
Age: 50 - 70+
Healthy Volunteers: Not accepted
Enrollment
11000 participants
Anticipated
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary purpose
Treatment
Arms
experimental: Olpasiran
placebo comparator: Placebo
Interventions
Olpasiran
Placebo
Primary outcome measure
Central contacts
Locations
Advanced Cardiovascular LLC
Recruiting
Alexander City, Alabama, United States, 35010
University of Alabama Birmingham Saint Vincents Birmingham
Recruiting
Birmingham, Alabama, United States, 35205
Birmingham Clinical Research
Recruiting
Birmingham, Alabama, United States, 35209
Alliance For Multispecialty Research - Daphne
Recruiting
Daphne, Alabama, United States, 36526
Eastern Shore Research Institute
Recruiting
Fairhope, Alabama, United States, 36532
Heart Center Research LLC
Recruiting
Huntsville, Alabama, United States, 35801
CB Flock Research Corporation
Recruiting
Mobile, Alabama, United States, 36608
Phoenix Clinical
Recruiting
Phoenix, Arizona, United States, 85014
Elite Clinical Studies LLC
Recruiting
Phoenix, Arizona, United States, 85018
Hero Clinical Research
Recruiting
Phoenix, Arizona, United States, 85021
HonorHealth Research Institute
Recruiting
Scottsdale, Arizona, United States, 85258
Eclipse Clinical Research
Recruiting
Tucson, Arizona, United States, 85745
Lynn Institute of the Ozarks
Recruiting
Little Rock, Arkansas, United States, 72204
National Heart Institute
Recruiting
Beverly Hills, California, United States, 90211
310 Clinical Research
Recruiting
Inglewood, California, United States, 90301
University of California San Diego
Recruiting
La Jolla, California, United States, 92037
InvivoCure
Recruiting
Los Angeles, California, United States, 91405
Valley Clinical Trials
Recruiting
Northridge, California, United States, 91325
Clinical Trials Research - Sacramento
Recruiting
Roseville, California, United States, 95661
Alliance Clinical Research
Recruiting
San Diego, California, United States, 92120
Encompass Clinical Research
Recruiting
Spring Valley, California, United States, 91978
Stanford Health Care
Recruiting
Stanford, California, United States, 94305
Manshadi Heart Institute
Recruiting
Stockton, California, United States, 95204
Blue Coast Cardiology
Recruiting
Vista, California, United States, 92083
Diablo Clinical Research
Recruiting
Walnut Creek, California, United States, 94598
Focus Clinical Research
Recruiting
West Hills, California, United States, 91307
Interventional Cardiology Medical Group
Recruiting
West Hills, California, United States, 91307
UCHealth Memorial Central
Recruiting
Colorado Springs, Colorado, United States, 80909
South Denver Cardiology Associates
Recruiting
Littleton, Colorado, United States, 80120
Gandelman Cardiology, PC
Recruiting
Greenwich, Connecticut, United States, 06830
ClinTrial Hamden
Recruiting
Hamden, Connecticut, United States, 06518
Chase Medical Research LLC
Recruiting
Waterbury, Connecticut, United States, 06708
Excel Medical Clinical Trials
Recruiting
Boca Raton, Florida, United States, 33434
Clearwater Cardiovascular Consultants
Recruiting
Clearwater, Florida, United States, 33756
Jacksonville Center for Clinical Research
Recruiting
Jacksonville, Florida, United States, 32216
East Coast Institute for Research, LLC
Recruiting
Lake City, Florida, United States, 32055
Columbus Clinical Services LLC
Recruiting
Miami, Florida, United States, 33125
Kendall South Medical Center
Recruiting
Miami, Florida, United States, 33175
Inpatient Research Clinic, LLC
Recruiting
Miami Lakes, Florida, United States, 33014
Panax Clinical Research
Recruiting
Miami Lakes, Florida, United States, 33014
Indago Research and Health Center
Recruiting
Miami Lakes, Florida, United States, 33016
Eminat, LLC
Recruiting
Miramar, Florida, United States, 33027
Suncoast Clinical Research Inc
Recruiting
New Port Richey, Florida, United States, 34652
Ocala Cardiovascular Research
Recruiting
Ocala, Florida, United States, 34471
Ocala Research Institute, Inc
Recruiting
Ocala, Florida, United States, 34474
Ormond Beach Clinical Research
Recruiting
Ormond Beach, Florida, United States, 32174
Baptist Health Care
Recruiting
Pensacola, Florida, United States, 32503
Denali Health Plant City
Recruiting
Plant City, Florida, United States, 33563
Clinical Site Partners Orlando dba Flourish Research
Recruiting
Winter Park, Florida, United States, 32789
Emory University Hospital
Recruiting
Atlanta, Georgia, United States, 30322
East Coast Institute for Research
Recruiting
Canton, Georgia, United States, 30114
Northeast Georgia Medical Center Wisteria Building
Recruiting
Cumming, Georgia, United States, 30041
Nsc Research
Recruiting
Johns Creek, Georgia, United States, 30024
Georgia Clinical Research
Recruiting
Lawrenceville, Georgia, United States, 30044
North Georgia Clinical Research
Recruiting
Woodstock, Georgia, United States, 30189
St Lukes Idaho
Recruiting
Meridian, Idaho, United States, 83642
Endeavor Health-Northwest Community Healthcare
Recruiting
Arlington Heights, Illinois, United States, 60005
Christie Clinic
Recruiting
Champaign, Illinois, United States, 61822
Advocate Lutheran General Hospital
Recruiting
Park Ridge, Illinois, United States, 60068
Alliance for Multispecialty Research LLC - Park Ridge
Recruiting
Park Ridge, Illinois, United States, 66068
MediSphere Medical Research Center LLC
Recruiting
Evansville, Indiana, United States, 47714
Parkview Research Center
Recruiting
Fort Wayne, Indiana, United States, 46845
Franciscan Health Indianapolis
Recruiting
Indianapolis, Indiana, United States, 46237
Ascension Saint Vincent Heart Center
Recruiting
Indianapolis, Indiana, United States, 46290
Cardiovascular Research of Northwest Indiana LLC
Recruiting
Munster, Indiana, United States, 46321
Reid Physician Associates
Recruiting
Richmond, Indiana, United States, 47374
MercyOne Iowa Heart Center
Recruiting
West Des Moines, Iowa, United States, 50266
Hutchinson Clinic PA
Recruiting
Hutchinson, Kansas, United States, 67502
University of Kansas Medical Center
Recruiting
Kansas City, Kansas, United States, 66160
Midwest Heart and Vascular Specialists
Recruiting
Overland Park, Kansas, United States, 66211
Graves Gilbert Clinic
Recruiting
Bowling Green, Kentucky, United States, 42101
Baptist Health Lexington
Recruiting
Lexington, Kentucky, United States, 40503
The Research Group of Lexington LLC
Recruiting
Lexington, Kentucky, United States, 40503
Heart Clinic of Hammond
Recruiting
Covington, Louisiana, United States, 70433
IMA Clinical Research
Recruiting
Monroe, Louisiana, United States, 71201
Louisiana Heart Center
Recruiting
Slidell, Louisiana, United States, 70458
Monroe Research LLC
Recruiting
West Monroe, Louisiana, United States, 71291
Ascension Saint Agnes Heart Care
Recruiting
Baltimore, Maryland, United States, 21229
Johns Hopkins Hospital
Recruiting
Baltimore, Maryland, United States, 21287
Metropolitan Cardiovascular Consultants LLC
Recruiting
Beltsville, Maryland, United States, 20705
Flourish Research
Recruiting
Bowie, Maryland, United States, 20715
Johns Hopkins University
Recruiting
Columbia, Maryland, United States, 21044
Centennial Medical Group
Recruiting
Columbia, Maryland, United States, 21045
Capitol Cardiology Associates
Recruiting
Lanham, Maryland, United States, 20706
MedStar Health Research Institute
Recruiting
Olney, Maryland, United States, 20832
Brigham and Womens Hospital
Recruiting
Boston, Massachusetts, United States, 02115
Henry Ford Health System
Recruiting
Detroit, Michigan, United States, 48202
Healthy Heart Cardiology
Recruiting
Grand Rapids, Michigan, United States, 49546
MyMichigan Medical Center Midland - Clinical Research Department
Recruiting
Midland, Michigan, United States, 48670
Advanced Cardiology Associates
Recruiting
Rochester Hills, Michigan, United States, 48307
Revival Research Institute
Recruiting
Southfield, Michigan, United States, 48034
Saint Marys Medical Center
Recruiting
Duluth, Minnesota, United States, 55805
Health East Cancer Care
Recruiting
Maplewood, Minnesota, United States, 55109
University of Minnesota
Recruiting
Minneapolis, Minnesota, United States, 55455
Mayo Clinic
Recruiting
Rochester, Minnesota, United States, 55905
Methodist Hospital
Recruiting
Saint Louis Park, Minnesota, United States, 55426
Jackson Heart Clinic
Recruiting
Jackson, Mississippi, United States, 39216
Cardiology Associates Research LLC
Recruiting
Tupelo, Mississippi, United States, 38801
Sisters of Saint Mary Health Heart and Vascular Care
Recruiting
Bridgeton, Missouri, United States, 63044
Kansas City Veterans Affairs Medical Center
Recruiting
Kansas City, Missouri, United States, 64128
Washington University
Recruiting
St Louis, Missouri, United States, 63110
Bryan Heart
Recruiting
Lincoln, Nebraska, United States, 68506
Physician Research Collaboration, LLC
Recruiting
Lincoln, Nebraska, United States, 68516
Excel Clinical Research
Recruiting
Las Vegas, Nevada, United States, 89109
American Institute of Medical Research
Recruiting
Las Vegas, Nevada, United States, 89123
Las Vegas Clinical Trials
Recruiting
North Las Vegas, Nevada, United States, 89030
Renown Institute for Heart and Vascular Health
Recruiting
Reno, Nevada, United States, 89502
Advanced Heart Care LLC
Recruiting
Bridgewater, New Jersey, United States, 08807
Advanced Heart and Vascular Institute of Hunterdon
Recruiting
Flemington, New Jersey, United States, 08822
Clinical Reseach Philadelphia Pennington
Recruiting
Hamilton, New Jersey, United States, 08690
Med Clinical Research Partners - Irvington
Recruiting
Irvington, New Jersey, United States, 07111
New Jersey Medcare / New Jersey Heart
Recruiting
Linden, New Jersey, United States, 07036
Saint Michaels Medical Center
Recruiting
Newark, New Jersey, United States, 07102
Circuit Clinical / Optum Medical Care of New Jersey
Recruiting
Secaucus, New Jersey, United States, 07094
The Heart House - Washington Township
Recruiting
Sewell, New Jersey, United States, 08080
CardioMetabolic Collaborative Clinic
Recruiting
Somerset, New Jersey, United States, 08873
Ima Clinical Research - Warren
Recruiting
Warren Township, New Jersey, United States, 07059
Albany Medical College
Recruiting
Albany, New York, United States, 12203
Basil Clinical
Recruiting
Inwood, New York, United States, 11096
Rasai Research
Recruiting
Jackson Heights, New York, United States, 11372
Crystal Run Healthcare
Recruiting
Monroe, New York, United States, 10950
Icahn School of Medicine at Mount Sinai
Recruiting
New York, New York, United States, 10029
Mount Sinai Queens
Recruiting
New York, New York, United States, 10029
Niagara Falls Memorial Medical Center
Recruiting
Niagara Falls, New York, United States, 14304
Circuit Clinical Orchard Park Family Practice
Recruiting
Orchard Park, New York, United States, 14127
Hudson Valley Cardiovascular Physicians PC
Recruiting
Poughkeepsie, New York, United States, 12601
Saratoga Clinical Research, LLC
Recruiting
Saratoga Springs, New York, United States, 12866
Duke University Health System
Recruiting
Durham, North Carolina, United States, 27710
Moses H Cone Memorial Hospital
Recruiting
Greensboro, North Carolina, United States, 27401
Medication Management LLC
Recruiting
Greensboro, North Carolina, United States, 27405
Triad Clinical Trials, LLC
Recruiting
Greensboro, North Carolina, United States, 27410
ClinCept, LLC
Recruiting
Kinston, North Carolina, United States, 28501
Monroe Biomedical Research
Recruiting
Monroe, North Carolina, United States, 28112
Piedmont Healthcare
Recruiting
Statesville, North Carolina, United States, 28625
Accellacare Research of Wilmington
Recruiting
Wilmington, North Carolina, United States, 28401
Wake Forest University Health Sciences
Recruiting
Winston-Salem, North Carolina, United States, 27157
Lillestol Research LLC
Recruiting
Fargo, North Dakota, United States, 58104
Aultman Cardiology Clinical Trials
Recruiting
Canton, Ohio, United States, 44710
The Christ Hospital
Recruiting
Cincinnati, Ohio, United States, 45219
Velocity Clinical Research - Cincinnati
Recruiting
Cincinnati, Ohio, United States, 45219
Nexgen Research
Recruiting
Lima, Ohio, United States, 45801
K and R Research
Recruiting
Marion, Ohio, United States, 43302
Alliance for Multispecialty Research
Recruiting
Norman, Oklahoma, United States, 73069
University of Pennsylvania
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Preferred Primary Care Physicians, Inc
Recruiting
Pittsburgh, Pennsylvania, United States, 15236
Pottstown Medical Specialists Inc
Recruiting
Pottstown, Pennsylvania, United States, 19464
Miriam Hospital
Recruiting
East Greenwich, Rhode Island, United States, 02818
Pharmacorp Clinical Trials Inc
Recruiting
Charleston, South Carolina, United States, 29412
Medical University of South Carolina
Recruiting
Charleston, South Carolina, United States, 29425
Prisma Health Carolina Cardiology - Greenville
Recruiting
Gantt, South Carolina, United States, 29605
Walker Family Care
Recruiting
Little River, South Carolina, United States, 29566
Accellacare Charleston
Recruiting
Mt. Pleasant, South Carolina, United States, 29464
Tribe Clinical Research - Spartanburg
Recruiting
Spartanburg, South Carolina, United States, 29301
Monument Health Clinical Research
Recruiting
Rapid City, South Dakota, United States, 57701
Erlanger Health, Inc.
Recruiting
Chattanooga, Tennessee, United States, 37403
Ascension Saint Thomas
Recruiting
Nashville, Tennessee, United States, 37205
Parkway Cardiology Associates
Recruiting
Oak Ridge, Tennessee, United States, 37830
Tennessee Center for Clinical Trials
Recruiting
Tullahoma, Tennessee, United States, 37388
PharmaTex Research, LLC
Recruiting
Amarillo, Texas, United States, 79106
Texas Diabetes and Endocrinology
Recruiting
Austin, Texas, United States, 78731
Ima Clinical Research
Recruiting
Austin, Texas, United States, 78745
Pioneer Medical Associates
Recruiting
Carrollton, Texas, United States, 75007
Baylor Scott and White Heart and Vascular Hospital-Dallas
Recruiting
Dallas, Texas, United States, 75226
Zenos Clinical Research
Recruiting
Dallas, Texas, United States, 75230
The Heartbeat Clinic
Recruiting
Dallas, Texas, United States, 75243
Cedar Health Research, LLC
Recruiting
Dallas, Texas, United States, 75251
Cedar Health Research, LLC
Recruiting
Euless, Texas, United States, 76040
East Texas Cardiology PA
Recruiting
Houston, Texas, United States, 77002
Baylor College of Medicine
Recruiting
Houston, Texas, United States, 77030
Cardiovascular Specialists of Willowbrook
Recruiting
Houston, Texas, United States, 77070
Vital Heart and Vein
Recruiting
Humble, Texas, United States, 77338
Tcr Institute Llc
Recruiting
Kingwood, Texas, United States, 77339
Epic Clinical Research
Recruiting
Lewisville, Texas, United States, 75057
Texas Tech University Health Sciences Center
Recruiting
Lubbock, Texas, United States, 79430
Revival Research Institute
Recruiting
McKinney, Texas, United States, 75071
Texas Institute of Cardiology
Recruiting
McKinney, Texas, United States, 75071
Southern Endocrinology Associates PA
Recruiting
Mesquite, Texas, United States, 75149
Orion Medical
Recruiting
Pasadena, Texas, United States, 77505
Valley Institute of Research Plano
Recruiting
Plano, Texas, United States, 75024
Ima Clinical Research San Antonio
Recruiting
San Antonio, Texas, United States, 78229
St Davids Heart & Vascular PLLC dba Austin Heart
Recruiting
San Marcos, Texas, United States, 78666
Tyler Cardiovascular Consultants
Recruiting
Tyler, Texas, United States, 75701
Alpine Research Organization
Recruiting
Layton, Utah, United States, 84041
Inova Cardiology - Fairfax
Recruiting
Fairfax, Virginia, United States, 22031
Virginia Heart
Recruiting
Falls Church, Virginia, United States, 22042
Virginia Heart - Loudoun
Recruiting
Leesburg, Virginia, United States, 20176
Carient Heart and Vascular
Recruiting
Manassas, Virginia, United States, 20109
Bon Secours Cardiology
Recruiting
Midlothian, Virginia, United States, 23114
Tidewater Physicians Multispecialty Group Clinical Research
Recruiting
Newport News, Virginia, United States, 23606
Alliance for Multispecialty Research Norfolk
Recruiting
Norfolk, Virginia, United States, 23502
Centricity Research
Recruiting
Suffolk, Virginia, United States, 23435
Selma Medical Associates
Recruiting
Winchester, Virginia, United States, 22601
Western Washington Medical Group
Recruiting
Everett, Washington, United States, 98208
Rainier Clinical Research Center
Recruiting
Renton, Washington, United States, 98057
Centricity Research Calgary
Recruiting
Calgary, Alberta, Canada, T2H 2G4
Edmonton Cardiology Consultants
Recruiting
Edmonton, Alberta, Canada, T5H 4B9
Fraser Clinical Trials
Recruiting
New Westminster, British Columbia, Canada, V3L 3W4
SMH Cardiology Clinical Trials Incorporated
Recruiting
Surrey, British Columbia, Canada, V3V 0C6
ARC Biosystems Incorporated
Recruiting
Vancouver, British Columbia, Canada, V6Z 1Y6
Victoria Heart Institute Foundation
Recruiting
Victoria, British Columbia, Canada, V8R 1B2
Discovery Clinical Services Ltd
Recruiting
Victoria, British Columbia, Canada, V8T 5G4
Centricity Research Brampton
Recruiting
Brampton, Ontario, Canada, L6S 0C6
Circulate Cardiac & Vascular Centre
Recruiting
Burlington, Ontario, Canada, L7M 1K9
Cambridge Cardiac Care Centre
Recruiting
Cambridge, Ontario, Canada, N1R 6V6
Hamilton Health Sciences Hamilton General Hospital
Recruiting
Hamilton, Ontario, Canada, L8L 2X2
St Josephs Hospital
Recruiting
London, Ontario, Canada, N6A 4V2
Elevate Clinical Research KMH Missisauga
Recruiting
Mississauga, Ontario, Canada, L5K 2L3
Partners in Advanced Cardiac Evaluation
Recruiting
Newmarket, Ontario, Canada, L3Y 8C3
North York Diagnostic and Cardiac Centre
Recruiting
North York, Ontario, Canada, M6B 3H7
Oakville Cardiovascular Research
Recruiting
Oakville, Ontario, Canada, L6K 3W7
Heart Health Institute Research Incorporated
Recruiting
Scarborough Village, Ontario, Canada, M1B 4Z8
Womens College Hospital
Recruiting
Toronto, Ontario, Canada, M5S 1B2
Ecogene-21
Recruiting
Chicoutimi, Quebec, Canada, G7H 7K9
Montreal Heart Institute
Recruiting
Montreal, Quebec, Canada, H1T 1C8
Institut de recherches cliniques de Montreal
Recruiting
Montreal, Quebec, Canada, H2W 1R7
Centre de Recherche du Centre Hospitalier de l Universite de Montreal
Recruiting
Montreal, Quebec, Canada, H2W 1T8
Research Institute of McGill University Health Center - Glen Site
Recruiting
Montreal, Quebec, Canada, H4A 3J1
CIUSSS de l Estrie CHUS Hopital Fleurimont
Recruiting
Sherbrooke, Quebec, Canada, J1H 5N4
Sponsor
Amgen
Last update posted
Aug 21, 2026
Last verified
Aug, 2026
Keywords
Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-07. This information was provided to ClinicalTrials.gov by Amgen on 2026-08-21.