Recruiting

Mindfulness Intervention

Sponsor:

Columbia University

Code:

NCT07140094

Conditions

Long COVID

Long Covid19

Post-Acute COVID-19

Post-Acute COVID-19 Syndrome

Post-Acute COVID-19 Infection

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Structured mindfulness intervention

Study Details

Brief summary:

This research is being done to study a mindfulness intervention among people who have symptoms of Post-Acute Sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID. Mindfulness is defined as paying attention to the present moment with non-judgment and acceptance. Here the investigators are studying whether a mindfulness intervention can help reduce stress, reduce Long COVID symptoms, and improve quality of life among people living with Long COVID. The mindfulness intervention is a series of recorded mindfulness sessions, which were created by the study team. People who decide to take part will be randomly assigned to receive the study mindfulness intervention immediately after joining the study or to receive the study mindfulness intervention 8 weeks after joining the study. All participants will continue their usual medical care. Participants will complete online surveys to measure symptoms over time. The study will last 6 months.

Conditions

Long COVID

Long Covid19

Post-Acute COVID-19

Post-Acute COVID-19 Syndrome

Post-Acute COVID-19 Infection

Study ID

NCT07140094

Start date

May 21, 2024

Status verified date

Aug, 2026

Completion date

Nov 21, 2027

Anticipated

Primary completion date

May 21, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age > or = 18
  • Willing and able to provide informed consent
  • Access to the internet
  • Self-reported history of SARS-CoV-2 infection
  • Current symptoms attributed to PASC by participant or by participant's medical provider; ongoing symptoms that persisted >= 12 weeks after Covid-19 illness

Exclusion Criteria:

  • Participating in another clinical trial of an intervention for PASC symptoms
  • Engaged in a structured MBI

Study Design

Enrollment

400 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

other: Group 1 - Receives Mindfulness Based Intervention (MBI) Immediately

Group 1 participants will receive the study mindfulness intervention at the beginning of the study, along with their regular treatment as usual (through their medical providers)

other: Group 2 - Receives Intervention with 8-week Delay

Group 2 will begin the study with treatment as usual; they will receive the study mindfulness intervention two months after study enrollment.

Interventions

Structured mindfulness intervention

The mindfulness intervention is a series of recorded mindfulness sessions, which were created by the study team. The mindfulness recordings are between two and twenty minutes long and are accessed online.

Primary outcome measure

  • Mean Score of Patient-Reported Outcomes Measurement Information System (PROMIS) Global 10 Score [ Time Frame: Month 2 ]

Central Contacts and Locations

Central contacts

Deborah Theodore, MD

2123058739dat2132@cumc.columbia.edu

Locations

Columbia University

Recruiting

New York, New York, United States, 10032

Contacts

Deborah Theodore, MD

212-305-8739dat2132@cumc.columbia.edu

More Information

Sponsor

Columbia University

Last update posted

Aug 31, 2026

Last verified

Aug, 2026

Keywords

  • Covid

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Columbia University on 2026-08-31.