Recruiting

RFA

Sponsor:

M.D. Anderson Cancer Center

Code:

NCT07140757

Conditions

Low Risk

Papillary Thyroid Cancer

Radiofrequency Ablation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Questionnaire

Study Details

Brief summary:

To track the outcomes of patients who have been treated with RFA and its long-term effectiveness, and to learn more about the quality of life of patients who have received RFA in this study.

Conditions

Low Risk

Papillary Thyroid Cancer

Radiofrequency Ablation

Study ID

NCT07140757

Start date

Aug 18, 2025

Status verified date

Mar, 2026

Completion date

Dec 31, 2030

Anticipated

Primary completion date

Dec 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Eligibility Criteria

1. Participants scheduled to undergo ultrasound-guided RFA for the following conditions: benign thyroid nodules, indeterminate thyroid nodules, low-risk DTC, and recurrent PTC
2. Participant is over 18 years and is either not a surgical candidate or has declined surgery.
3. Capable and willing to provide written informed consent
4. Participant has one of the following diagnoses:

  • Biopsy-proven benign thyroid nodules causing compressive and/or cosmetic symptoms who are requesting treatment,
  • Biopsy-proven indeterminate nodules (AUS or follicular neoplasm)
  • Papillary thyroid carcinoma (PTC) without metastasis
  • Locally recurrent thyroid cancer (< 2 cm).

Exclusion Criteria

1. Participants meeting any of the following criteria will be excluded:
2. Participants considered unsuitable for RFA by the treating physician

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Interventions

Questionnaire

This questionnaire includes twenty-four questions covering patients complaints ranging from 0 to 4. Patients will be asked about the presence and severity of each item currently on the medical appointment.

Primary outcome measure

  • Health- related Quality of Life Questionnaires [ Time Frame: Through study completion; an average of 1 year ]

Central Contacts and Locations

Central contacts

Victoria E Banuchi, MD

346-217-8668vebanuchi@mdanderson.org

Locations

MD Anderson Cancer Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Victoria E Banuchi, MD

346-217-8668VEBanuchi@mdanderson.org

Principal Investigator:

Victoria E Banuchi, MD

More Information

Sponsor

M.D. Anderson Cancer Center

Last update posted

Mar 11, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by M.D. Anderson Cancer Center on 2026-03-11.