OSC/SS ProcedureRetinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)

Inclusion Criteria:

1. No contraindications to laser retinopexy surgery per local site criteria.
2. Capable of giving signed informed consent, and assent (as appropriate)
3. Signature of research informed consent form from participant, or participant's legally authorized representative (LAR)/parent(s)/legal guardian
4. Male or female of any age
5. SS type 1 or type 2 confirmed by genetic testing

Exclusion Criteria:

1. Presence of media opacity (for example, dense cataract, corneal scar) or poor pupillary dilation that precludes adequate OSC/SS performance, laser treatment, or imaging.
2. Prior prophylactic laser treatment that cannot be supplemented to achieve a complete OSC/SS pattern or exceeds the designated OSC/SS pattern.
3. RD in the eye to be treated.
4. Significant intraocular hemorrhage in the eye to be treated.
5. Uncontrolled ocular conditions (e.g., glaucoma) that may be worsened by the procedure or preclude follow-up.
6. Any other ocular condition that precludes the ability to perform adequate laser treatment under scleral depression.
7. Any systemic medical contraindication where the risk of intervention outweighs the potential benefit.
8. Known pathogenic mutations in genes associated with other inherited retinal detachment syndromes, including but not limited to: FEVR-related genes: FZD4, LRP5, TSPAN12, NDPX-linked retinoschisis (RS1) Wagner Syndrome (VCAN).
9. Other syndromes associated with increased risk of retinal detachment (for example, Knobloch syndrome, Marfan syndrome, Pierson syndrome).
10. History of Coats disease.
11. History of Retinopathy of Prematurity (with or without laser treatment).
12. Prior laser photocoagulation in the study eye for any indication other than the following: retinal detachment prophylaxis for Stickler syndrome, treatment of lattice degeneration, or treatment of retinal tears.
13. Laser photocoagulation, for the indications permitted in exclusion criteria 12, that cannot be supplemented to meet the OSC/SS criteria.
14. Previous cryopexy.
15. Previous scleral buckle.
16. Previous vitrectomy in the study eye for any reason.
17. Significant peripheral retinal pathology unrelated to Stickler that increases the risk of retinal detachment including but not limited to: retinoschisis, hemorrhages, angiomatous lesions, pars planitis.
18. History of ocular trauma with significant trauma to the posterior segment of the eye and may increase the risk of retinal detachment including Ruptured globe, Vitreous hemorrhage, Commotio retinae, Traumatic macular hole, Intraocular foreign body.
19. Inability or unwillingness to comply with required follow-up schedule (clinical visits, imaging).
20. Anticipated relocation, foster care instability, or any factor significantly limiting longitudinal follow-up.
21. Investigator judgment: Any condition not listed above that could interfere with the trial's integrity or subject safety.