Recruiting

Radiation Therapy

Sponsor:

Abramson Cancer Center at Penn Medicine

Code:

NCT07147179

Conditions

Central Nervous System Cancer

Eligibility Criteria

Sex: All

Age: 0 - 21

Healthy Volunteers: Not accepted

Interventions

Short Course Radiotherapy

Study Details

Brief summary:

This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous system malignancies.

Conditions

Central Nervous System Cancer

Study ID

NCT07147179

Start date

Apr 2, 2026

Status verified date

Apr, 2026

Completion date

Mar, 2027

Anticipated

Primary completion date

Mar, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 21

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Male or female, aged 21 years or below
  • Lansky performance status >= 40
  • Has a diagnosis of an incurable malignancy that:

  • Originates outside the brain but is metastatic to 1 or more sites within the brain, or originates and recurs within the brain. For this diagnosis to be confirmed, there must be multidisciplinary review of up to date imaging at a pediatric tumor board with unanimous consensus of intracranial relapse or metastasis. If the consensus is not unanimous, short-interval repeat imaging with subsequent unanimous consensus would be required in order for this eligibility criteria to be met
  • Has at least 1 targetable intracranial lesion as seen on imaging
  • Has a multidisciplinary consensus recommendation for palliative intent radiation
  • Consents to the study or has caregiver who is able to provide signed and dated informed consent. For subjects under the age of 18, a signed and dated assent form as able.
  • Patients who had prior radiation in planned treatment area are also eligible to enter the trial
  • Stated willingness to comply with all study procedures and availability for the duration of the study

Exclusion Criteria:

  • Radiotherapy for curative intent
  • Serious uncontrolled systemic or psychiatric disorders that would interfere with participation in the protocol
  • Being planned for proton radiation

Study Design

Enrollment

15 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Short Course Radiotherapy

Short-course radiation therapy in pediatric patients with incurable central nervous system malignancies

Interventions

Short Course Radiotherapy

Participants will receive a shorter course of radiation therapy across 5 days (20 Gray in 5 fractions).

Primary outcome measure

  • Safety of Short Course Radiotherapy [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Kelly Clark

267-854-5332Kelly.Clark3@pennmedicine.upenn.edu

Locations

University of Pennsylvania

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Kelly Clark

267-854-5332Kelly.Clark3@pennmedicine.upenn.edu

Principal Investigator:

Michael LaRiviere, MD

More Information

Sponsor

Abramson Cancer Center at Penn Medicine

Last update posted

May 5, 2026

Last verified

Apr, 2026

Keywords

  • Short Course
  • Radiotherapy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Abramson Cancer Center at Penn Medicine on 2026-05-05.