Recruiting
Phase 2
Phase 3

Cannabidiol

Sponsor:

Johns Hopkins University

Code:

NCT07148843

Conditions

Alcohol Use Disorder (AUD)

Withdrawal From Addictive Substance; Detoxification

Craving

Eligibility Criteria

Sex: All

Age: 21 - 65

Healthy Volunteers: Not accepted

Interventions

Cannabidiol (CBD)

Placebo

Study Details

Brief summary:

Cannabidiol (CBD), one of the most prevalent cannabinoids in cannabis (marijuana) has been shown to reduce alcohol withdrawal symptoms in laboratory animals. In people without alcohol use disorder (AUD), CBD has been show to be effective in reducing anxiety, sleep problems, and seizures; all of these are common symptoms of alcohol withdrawal. This randomized placebo-controlled clinical trial will evaluate the potential of CBD to improve alcohol withdrawal symptoms and reduce craving during acute abstinence among individuals with moderate-to-severe AUD. Adult participants with moderate-to-severe AUD will be admitted to an inpatient research unit at the Johns Hopkins Hospital for a 5-day, 4-night stay that includes alcohol abstinence with management of their alcohol withdrawal. In addition to standard care, participants will receive CBD or placebo (no CBD), complete assessments of withdrawal, sleep quality and provide breath and blood samples.

Conditions

Alcohol Use Disorder (AUD)

Withdrawal From Addictive Substance; Detoxification

Craving

Study ID

NCT07148843

Start date

Nov 1, 2026

Status verified date

Sep, 2026

Completion date

Oct 31, 2030

Anticipated

Primary completion date

Oct 31, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria

  • Meets DSM-5 criteria Moderate or Severe Alcohol Use Disorder
  • Age 21-65
  • Report at least one prior episode of alcohol withdrawal symptoms at least one day in duration that caused significant impairment in functioning (i.e., unable to attend work or engage in typical activities) AND/OR required medications to manage symptoms.
  • Report at least 21 days of heavy drinking (four or more drinks for women, five or more drinks for men) over the last 28 days.
  • if female of childbearing potential who has not had a sterilization procedure:
  • Negative human chorionic gonadotropin (hCG) on qualitative urine pregnancy screen
  • Agree to use a highly effective method of contraception (e.g. hormonal contraception, intrauterine device, double-barrier method) for at least five days prior to administration of the study drug and throughout the duration of the study
  • Shipley vocabulary score > 18, corresponding to 5th grade reading level.
  • Demonstrated understanding of informed consent and ability to consent to participation in the study.

Exclusion Criteria

  • Current or past alcohol-related medical complications including but not limited to cirrhosis of the liver, esophageal varices, pancreatitis, severe gastritis, hemoptysis, hematochezia, or melena.
  • Use of gabapentin, benzodiazepines, or other sedative-hypnotic medications within the week prior to admission
  • Regular use (i.e. twice a week or more) of CBD-dominant products, including Epidiolex®, within the last three months
  • Regular use of benzodiazepines (e.g., twice a week or more) within the last three months
  • Meet DSM-5 criteria for moderate-to-severe substance use disorder (SUD), including moderate-to-severe Cannabis Use Disorder (except for alcohol- and tobacco-related disorders)
  • •Urine drug screen indicating the presence of substances other than cannabis at screening.
  • Active suicidal ideation or recent suicide attempts (e.g. within six months)
  • Unstable and/or compromising medical or psychiatric conditions that would interfere with participant safety as determined by study physician.
  • Current pregnancy
  • BMI <18.5 kg/m2
  • History of anorexia nervosa or bulimia in the past 2 years
  • History of seizures or seizure disorder outside of alcohol-withdrawal related seizures
  • History of complicated alcohol withdrawal (e.g. seizures, delirium tremens) as verified by medical record review if available
  • Mean systolic blood pressure (SBP) >/= 140 mm Hg, DBP >/= 90 mmHg or pulse >/= 110 mm Hg during screening
  • Mean systolic blood pressure (SBP) >/=160 mm Hg, DBP>/=110 mm Hg, or pulse >/=120 mm Hg during pre-admission at Behavioral Pharmacology Research Unit (BPRU) prior to admission to CRU
  • Any of the following laboratory values during screening or upon admission:

  • AST > 165 U/L (normal range 19-55)
  • ALT > 216 U/L (normal range 19-72)
  • Alkaline phosphatase > 1.5x upper limit of normal (ULN) (normal range 38-126)
  • Total bilirubin >1.5 ULN (normal values=0.3-1.0 mg/dL)
  • Non-fasting glucose > 250 mg/ml (normal range 65-179)
  • Hematocrit < 38 % (normal range 41-53)
  • Hemoglobin < 12 g/dl (normal range 13.5-17.5) or any other laboratory value significantly outside the normal range
  • Use of a prescription medication (except for birth control prescriptions) within 14 days of study entry, which, in the opinion of the investigator or sponsor, will interfere with the study result or the safety of the subject. This includes any medication in which CYP2C9, CYP2C19, CYP1A2, CYP2B10, or CYP3A4 enzymes are major metabolizers. Participants taking medications that are substrates of UDP-glucuronosyltransferase 1-9 (UGT1A9), UDP-glucuronosyltransferase 2B7 (UGT2B7), CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and/or P-gp wll be allowed into the study but closely monitored for potential adverse events based on the prescribing information of the concomitant medications given CBD's potential to inhibit these enzymes.
  • Use of prescription medications, OTC medications, herbal medications, and/or dietary supplements that are strong inducers of CYP3A4 or CYP2C19 within 14 days or 5 half-lives (whichever is longer) prior to study drug administration
  • ECG with QT-corrected interval (QTc) > 450 ms and/or presence of clinically significant abnormality
  • Participation in other clinical trials within the past 60 days
  • Court-mandated participation in alcohol treatment or pending incarceration.
  • Known chronic liver disease or cirrhosis of any etiology (e.g. autoimmune, infections, Metabolic Dysfunction-Associated Steatohepatitis \[MASH\]\]) except in the following cases: 1. Fully resolved hepatitis B infection (HBsAg negative, anti-Hepatitis C core antibody (anti-HBc) and/or anti-Hepatitis B surface antibody (anti-HBs) positive, with normal liver function tests) or 2. Successfully treated hepatitis C infection (HCV RNA negative, with normal liver function tests and no evidence of advanced fibrosis or cirrhosis)
  • Recent acute hepatitis of any etiology (e.g. drug-induced hepatitis, hepatitis A infection within the past six months)
  • Moderate to severe hepatic impairment (Child-Pugh Class B and C)

Study Design

Enrollment

105 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: 10 mg/kg CBD

low dose CBD

active comparator: 20 mg/kg CBD

high dose CBD

placebo comparator: placebo

Placebo (no CBD)

Interventions

Cannabidiol (CBD)

Cannabidiol

Placebo

placebo

Primary outcome measure

  • Peak score on the Alcohol Withdrawal Symptom Checklist (AWSC) [ Time Frame: Four times daily during inpatient stay (4 nights) ]
  • Peak score on the Clinical Institute Withdrawal Assessment for Alcohol, revised (CIWA-Ar) [ Time Frame: 4 times daily during inpatient stay (4 nights) ]
  • Average total sleep time (minutes) and wake after sleep onset as measured by wrist actigraphy [ Time Frame: 4 nights during inpatient stay ]
  • Peak alcohol craving as measured by scores on the Alcohol Urge Questionnaire (AUQ) [ Time Frame: Four times daily during inpatient stay (4 nights) ]

Central Contacts and Locations

Central contacts

David Woliinsky, MD

(410) 550-0047dwolins2@jhmi.edu

Elise M Weerts, PhD

410-550-2781eweerts@jhmi.edu

Locations

Behavioral Pharmacology Research Unit

Recruiting

Baltimore, Maryland, United States, 21224

Contacts

David Wolinsky, MD

410-550-2253dwolins2@jhmi.edu

Elise Weerts, PhD

410-550-2781eweerts@jhmi.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Oct 2, 2026

Last verified

Sep, 2026

Keywords

  • alcohol abstinence
  • alcohol withdrawal treatment
  • detoxification

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-03. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-10-02. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.