Recruiting

Aerobic Exercise

Sponsor:

University of Alberta

Code:

NCT07150117

Conditions

Cancer

Adults

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Exercise

Study Details

Brief summary:

CYCLE-CIPN is a proof-of-concept study designed to evaluate whether a prescribed aerobic exercise intervention has the potential to reduce the symptoms and functional impact of CIPN. The small number of participants in the proposed study will allow us to make decisions on the feasibility ("go/no-go") of a future larger-scale trial.

The protocol will assess feasibility and acceptability through recruitment, completion, adherence, program satisfaction, and safety. The study will also evaluate CIPN symptoms using both patient-reported and objective outcome measures, as well as fitness and quality of life outcomes. We aim to recruit 30 participants.

The Health Research Board of Alberta Cancer Committee has approved this study. Participants will participate in a stationary cycling-based aerobic exercise program biweekly for 12 weeks. Exercise sessions will be supervised and progressive, between 30 and 60 minutes each.

Conditions

Cancer

Adults

Study ID

NCT07150117

Start date

Jan 26, 2026

Status verified date

Mar, 2026

Completion date

Jun 30, 2027

Anticipated

Primary completion date

Jan 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 18 years or older
  • Cancer diagnosis stage I to III
  • CIPN: grade 1 (mild)
  • Receiving or have received chemotherapy treatment for cancer
  • Speak, read and understand English

Exclusion Criteria:

  • Medical conditions that cause additional neuropathy symptoms (i.e. diabetes)
  • Any uncontrolled medical conditions
  • Will undergo surgery or radiation therapy during the study period
  • Are already receiving an aerobic exercise training program
  • Are already participating in an exercise-based research study
  • Are unable to provide signed informed consent

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Aerobic exercise intervention

Cycling-based aerobic exercise

Interventions

Exercise

A supervised 12-week cycling-based aerobic exercise intervention performed twice per week.

Primary outcome measure

  • Recruitment [ Time Frame: One year ]

Central Contacts and Locations

Central contacts

Christopher Sellar, PhD

1-780-492-6007frmace@ualberta.ca

Trei Lindstrom, BSc

1-780-492-6007frmace@ualberta.ca

Locations

Cross Cancer Institute

Recruiting

Edmonton, Alberta, Canada, T6G 1Z2

Contacts

Margaret McNeely, PhD

780-248-1531mmcneely@ualberta.ca

More Information

Sponsor

University of Alberta

Last update posted

Mar 12, 2026

Last verified

Mar, 2026

Keywords

  • peripheral neuropathy
  • chemotherapy
  • exercise
  • aerobic
  • cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Alberta on 2026-03-12.