Recruiting

Observational Study

Sponsor:

The University of Texas Health Science Center, Houston

Code:

NCT07157839

Conditions

Alzheimer&Amp;#39;s Disease

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Alzheimer's disease (AD) is characterized by the accumulation of tau pathology, and blood-based biomarkers such as phosphorylated tau-217 (pTau217) have been identified as sensitive and specific predictors of AD risk. Recent studies suggest that individuals with elevated pTau217 levels may be at increased risk for developing AD and cognitive dysfunction. This observational study will examine donated human plasma samples to determine whether some units of donated blood contain abnormally elevated pTau217 concentrations. The overarching goal is to evaluate whether transfusion of blood with higher pTau217 may pose risks to recipients and whether such units should be avoided in clinical use.

Conditions

Alzheimer&Amp;#39;s Disease

Study ID

NCT07157839

Start date

Aug 28, 2025

Status verified date

Feb, 2026

Completion date

Nov 1, 2026

Anticipated

Primary completion date

Nov 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • The plasma sample from donators.

Exclusion Criteria:

  • None.

Study Design

Enrollment

250 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Tau and pTau [ Time Frame: 6 months. ]
  • Concentration of pTau217 and Tau [ Time Frame: 6 months. ]

Central Contacts and Locations

Central contacts

Zhongcong Xie, M.D., Ph.D.

17135006207Zhongcong.Xie@uth.tmc.edu

Locations

University of Texas Health Science Center at Houston

Recruiting

Houston, Texas, United States, 77030

Contacts

Zhongcong Xie

7135006207Zhongcong.Xie@uth.tmc.edu

More Information

Sponsor

The University of Texas Health Science Center, Houston

Last update posted

Feb 11, 2026

Last verified

Feb, 2026

Keywords

  • Phosphorylated Tau, donated blood, Alzheimer's disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by The University of Texas Health Science Center, Houston on 2026-02-11.