Recruiting
Phase 1

Neuromodulation with Buprenorphine

Sponsor:

University of Minnesota

Code:

NCT07158853

Conditions

Opioid Use Disorder

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Transcranial Direct Current Stimulation (tDCS)

Study Details

Brief summary:

The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals taking medication for treatment for Opioid Use Disorder(OUD).

Conditions

Opioid Use Disorder

Study ID

NCT07158853

Start date

Feb 4, 2026

Status verified date

Jul, 2026

Completion date

Aug 31, 2027

Anticipated

Primary completion date

Aug 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Ability to provide consent and comply with study procedures
  • Diagnostic and Statistical Manual of Mental Disorders criteria for OUD
  • Undergoing medication treatment for OUD. Participants may have current comorbid drug use, but primary diagnosis must be OUD
  • Intention to remain in the study until intervention completion.

Exclusion Criteria:

  • Any medical condition with neurological sequelae
  • Head injury resulting in skull fracture or loss of consciousness of >30 minutes
  • Any tDCS or MRI contraindication (tDCS: history of seizures, metallic cranial plates/screws or implanted device, history of eczema on scalp. MRI: unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, or claustrophobia)
  • Any psychotic disorder (participants with other treated and stable psychiatric disorders will be included)
  • Presence of a condition that would render study measures impossible to administer or interpret
  • Age younger than 18
  • Primary current substance use disorder on a substance other than opioids except for caffeine or nicotine
  • In treatment instead of jail
  • Pregnancy
  • Disrespectful behavior towards the investigators and staff.

Study Design

Enrollment

40 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: tDCS

All intervention sessions will use the Soterix Mini-CT Remote tDCS device

Interventions

Transcranial Direct Current Stimulation (tDCS)

We will deliver 2-mA tDCS current intensity during a 30 minute stimulation period (including a 30-second ramp-up and 30-second ramp-down period) to the dorsolateral prefrontal cortex. Electrodes will be fixed on marked locations based on the 10-20 EEG system. Anodal stimulating electrode will be over the left DLPFC (F3) and cathodal electrode over the right DLPFC (F4).

Primary outcome measure

  • tDCS effect on circuit-based target engagement of a prefrontal-incentive salience network [ Time Frame: immediately after the intervention ]
  • tDCS effect on executive functioning [ Time Frame: immediately after the intervention ]

Central Contacts and Locations

Central contacts

Calvin Cahill

952-444-0137cahil138@umn.edu

Locations

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Calvin Cahill

952-444-0137cahil138@umn.edu

More Information

Sponsor

University of Minnesota

Last update posted

Jul 6, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-07-06.