Recruiting

WebMAP Onc

Sponsor:

St. Jude Children's Research Hospital

Code:

NCT07160621

Conditions

Childhood Cancer Survivor

Chronic Pain

Eligibility Criteria

Sex: All

Age: 10 - 17

Healthy Volunteers: Not accepted

Interventions

Cognitive Behavioral Therapy (CBT)

Education

Questionnaires

Study Details

Brief summary:

The purpose of the study is to determine if an adapted mobile cognitive behavioral therapy (CBT) app (WebMAP Onc) is more effective than standard pain education in reducing chronic pain and improving daily functioning in adolescent survivors of pediatric cancer.

This randomized study led by St. Jude Children's Research Hospital will involve 228 participants (114 adolescent survivors and 114 caregivers) across four U.S. hospitals. Outcomes include pain reduction, improved function, and the role of social determinants of health. Assessments occur at baseline, post-treatment, and 3-month follow-up.

Conditions

Childhood Cancer Survivor

Chronic Pain

Study ID

NCT07160621

Start date

Sep 5, 2025

Status verified date

Sep, 2026

Completion date

Jan, 2029

Anticipated

Primary completion date

Jan, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 10 - 17

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adolescent Participants

  • 10-17-year-old survivors of childhood cancer or those who received cancer directed therapies (e.g., Langerhan's Histiocytosis)
  • At least one-year post treatment completion
  • Pain present for 3 months or longer
  • Pain interfering with at least one area of daily functioning
  • Parent/Caregiver Participants

  • ≥ 18 years of age
  • Legally authorized to provide informed consent for the adolescent participant

Exclusion Criteria:

  • Adolescent Participants

  • Serious comorbid psychiatric condition
  • Current substance abuse as determined by the Substance Use Screening Questionnaire
  • History of development delay or significant cognitive impairment

  • Note: A participant who completed the feasibility study (ADAPTED) cannot participate in the subsequent clinical trial (ADAPTED2)
  • Parent/Caregiver Participants

  • Not fluent in English or Spanish
  • Unable to provide consent for own participation or for the participation of the adolescent participant

Study Design

Enrollment

116 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Arm I (mobile CBT)

Participants who are randomized to receive mobile CBT for chronic pain.

sham comparator: Arm II (Patient education)

Participants who are randomized to receive educational materials about chronic pain.

Interventions

Cognitive Behavioral Therapy (CBT)

Receive mobile CBT

Education

Receive educational materials

Questionnaires

Ancillary studies

Primary outcome measure

  • Pain intensity [ Time Frame: Up to 8 weeks from start of study ]
  • Pain interference [ Time Frame: Up to 8 weeks from start of study ]
  • Pain catastrophizing [ Time Frame: Up to 8 weeks from start of study ]
  • Depression [ Time Frame: Up to 8 weeks from start of study ]
  • Anxiety [ Time Frame: Up to 8 weeks from start of study ]
  • Cancer-related worry [ Time Frame: Up to 8 weeks from start of study ]
  • Physical functioning [ Time Frame: Up to 8 weeks from start of study ]
  • Peer relations [ Time Frame: Up to 8 weeks from start of study ]
  • Fatigue [ Time Frame: Up to 8 weeks from start of study ]
  • Sleep [ Time Frame: Up to 8 weeks from start of study ]
  • Opioid Use [ Time Frame: Up to 8 weeks from start of study ]

Central Contacts and Locations

Central contacts

Tara Brinkman, PhD

888-226-4343referralinfo@stjude.org

Tara Brinkman

8662785833referralinfo@stjude.org

Locations

St. Jude Children's Research Hospital

Recruiting

Memphis, Tennessee, United States, 38105

Contacts

Tara Brinkman, PhD

888-226-4343referralinfo@stjude.org

More Information

Sponsor

St. Jude Children's Research Hospital

Last update posted

Sep 3, 2026

Last verified

Sep, 2026

Keywords

  • Adult Caregiver
  • Adolescent Survivor

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by St. Jude Children's Research Hospital on 2026-09-03.