Recruiting

Precision Tobacco Treatment

Sponsor:

Washington University School of Medicine

Code:

NCT07166120

Conditions

Smoking Cessation

Smoking

Physician's Role

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Usual care

Precision treatment

Study Details

Brief summary:

This study evaluates the feasibility and preliminary effects of precision tobacco treatment, compared to usual care, on promoting tobacco treatment in oncology patients and providers in the oncology care setting. The precision treatment intervention includes personalized tobacco treatment recommendations using the patient's clinical, genetic, and biomarker information. This intervention may increase patient receipt of tobacco treatment, patient medication use, and patient smoking abstinence at 6 months.

Conditions

Smoking Cessation

Smoking

Physician's Role

Study ID

NCT07166120

Start date

Sep 11, 2025

Status verified date

Jul, 2026

Completion date

Sep 30, 2027

Anticipated

Primary completion date

Mar 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Eligibility Criteria for Clinicians:

  • Clinician from participating oncology/hematology clinic
  • At least 18 years of age
  • Can speak and understand English

Inclusion Criteria for Patients:

  • Patient at participating clinic
  • Age 18-89 years
  • Current smoking (average cigarettes per day ≥5)
  • Can speak and understand English
  • Willing to consider medication to help reduce craving or smoking such as nicotine patch, lozenge, or varenicline

Exclusion Criteria for Patients:

  • Active use of smoking cessation medication (within the past 30 days)
  • Receipt of smoking cessation medication or prescription for smoking cessation medication (within the past 30 days)
  • Having a contradiction for cNRT or varenicline (allergic reactions, current cardiac problems, pregnancy)
  • Patients who were deemed by the investigator to be ineligible for participation in the trial

Study Design

Enrollment

132 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: Usual Care

The arm will represent usual care in the oncology care clinics. Clinicians will receive a report designed to recommend guideline-based tobacco treatment. Patients will receive a report on guideline-based advice about smoking cessation and a brief discussion with a behavior interventionist.

experimental: PrecisionTx-Onc (oncology)

Clinicians will receive PrecisionTx-Onc, an intervention designed to recommend precision tobacco treatment, adapted for oncology. Patients will receive PrecisionTx-Onc, an intervention designed to recommend precision tobacco treatment, and a brief discussion with a behavior interventionist, adapted for oncology.

Interventions

Usual care

Usual care will be informed by practice guidelines (standard of care, brief advice, and guideline awareness).

Precision treatment

Precision treatment will be informed by practice guidelines (standard of care, brief advice, and guideline awareness), plus patient-specific risk feedback and personalized tobacco treatment recommendations using patients' clinical, genetic, and biomarker information, adapted for oncology.

Primary outcome measure

  • Patient receipt of tobacco treatment medication for smoking cessation [ Time Frame: 6 months post-intervention ]
  • Patient use of cessation medication [ Time Frame: 6 months post-intervention ]
  • Patient smoking abstinence [ Time Frame: 6 months post-intervention ]

Central Contacts and Locations

Central contacts

Li-Shiun Chen, ScD, M.D., MPH

314-362-3932li-shiun@wustl.edu

Theodore Thomas, M.D.

thomast@wustl.edu

Locations

John Cochran Veteran's Affairs Medical Center

Recruiting

St Louis, Missouri, United States, 63106

Contacts

Li-Shiun Chen, ScD, M.D.,MPH

314-362-3932li-shiun@wustl.edu

Principal Investigator:

Li-Shiun Chen, ScD, M.D.,MPH

Washington University School of Medicine

Recruiting

St Louis, Missouri, United States, 63110

Contacts

Li-Shiun Chen, ScD, M.D., MPH

314-362-3932li-shiun@wustl.edu

Theodore Thomas, M.D.

thomast@wustl.edu

Principal Investigator:

Li-Shiun Chen, ScD, M.D., MPH

More Information

Sponsor

Washington University School of Medicine

Last update posted

Jul 24, 2026

Last verified

Jul, 2026

Keywords

  • Genetics
  • Primary Care Physicians
  • Tobacco Treatment

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Washington University School of Medicine on 2026-07-24.